Heart Failure in the Era of Precision Medicine: A Scientific Statement from the American Heart Association

Sharon Cresci; Naveen L. Pereira; Ferhaan Ahmad; Mirnela Byku; Lisa De Las Fuentes; David E. Lanfear; Carolyn M. Reilly; Anjali T. Owens; Matthew J. Wolf

doi:10.1161/HCG.0000000000000058

Heart Failure in the Era of Precision Medicine: A Scientific Statement from the American Heart Association

Sharon Cresci, Naveen L. Pereira, Ferhaan Ahmad, Mirnela Byku, Lisa De Las Fuentes, David E. Lanfear, Carolyn M. Reilly, Anjali T. Owens, Matthew J. Wolf

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The "omics" - genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics - of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.

Original language	English (US)
Article number	e000058
Pages (from-to)	458-485
Number of pages	28
Journal	Circulation: Genomic and Precision Medicine
Volume	12
Issue number	10
DOIs	https://doi.org/10.1161/HCG.0000000000000058
State	Published - Oct 1 2019

Keywords

AHA Scientific Statements
early diagnosis
heart failure
precision medicine
preventive medicine

ASJC Scopus subject areas

Genetics
Cardiology and Cardiovascular Medicine
Genetics(clinical)

Access to Document

10.1161/HCG.0000000000000058

Cite this

@article{0d9e1a564c5e4f99b8f1eebad23db7c4,

title = "Heart Failure in the Era of Precision Medicine: A Scientific Statement from the American Heart Association",

abstract = "One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The {"}omics{"} - genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics - of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.",

keywords = "AHA Scientific Statements, early diagnosis, heart failure, precision medicine, preventive medicine",

author = "Sharon Cresci and Pereira, {Naveen L.} and Ferhaan Ahmad and Mirnela Byku and {De Las Fuentes}, Lisa and Lanfear, {David E.} and Reilly, {Carolyn M.} and Owens, {Anjali T.} and Wolf, {Matthew J.}",

note = "Funding Information: NIH (research grant to support investigations of cardiac hypertrophy)† Funding Information: PCORI†; NIH NHLBI (K23 HL105896)†; AHA (grant SFRN)† Publisher Copyright: {\textcopyright} 2019 Lippincott Williams and Wilkins. All rights reserved.",

year = "2019",

month = oct,

day = "1",

doi = "10.1161/HCG.0000000000000058",

language = "English (US)",

volume = "12",

pages = "458--485",

journal = "Circulation. Genomic and precision medicine",

issn = "1942-325X",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "10",

}

TY - JOUR

T1 - Heart Failure in the Era of Precision Medicine

T2 - A Scientific Statement from the American Heart Association

AU - Cresci, Sharon

AU - Pereira, Naveen L.

AU - Ahmad, Ferhaan

AU - Byku, Mirnela

AU - De Las Fuentes, Lisa

AU - Lanfear, David E.

AU - Reilly, Carolyn M.

AU - Owens, Anjali T.

AU - Wolf, Matthew J.

N1 - Funding Information: NIH (research grant to support investigations of cardiac hypertrophy)† Funding Information: PCORI†; NIH NHLBI (K23 HL105896)†; AHA (grant SFRN)† Publisher Copyright: © 2019 Lippincott Williams and Wilkins. All rights reserved.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The "omics" - genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics - of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.

AB - One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The "omics" - genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics - of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.

KW - AHA Scientific Statements

KW - early diagnosis

KW - heart failure

KW - precision medicine

KW - preventive medicine

UR - http://www.scopus.com/inward/record.url?scp=85073307298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073307298&partnerID=8YFLogxK

U2 - 10.1161/HCG.0000000000000058

DO - 10.1161/HCG.0000000000000058

M3 - Review article

C2 - 31510778

AN - SCOPUS:85073307298

SN - 1942-325X

VL - 12

SP - 458

EP - 485

JO - Circulation. Genomic and precision medicine

JF - Circulation. Genomic and precision medicine

IS - 10

M1 - e000058

ER -

Heart Failure in the Era of Precision Medicine: A Scientific Statement from the American Heart Association

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this