TY - JOUR
T1 - Heart failure after myocardial infarction
T2 - Prevalence of preserved left ventricular systolic function in the community
AU - Hellermann, Jens P.
AU - Jacobsen, Steven J.
AU - Reeder, Guy S.
AU - Lopez-Jimenez, Francisco
AU - Weston, Susan A.
AU - Roger, Véronique L.
N1 - Funding Information:
From the aDivision of Cardiovascular Diseases and Internal Medicine, and the bDepartment of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minn. Supported in part by grants from the Public Health Service and the National Institutes of Health (AR30582 and RO1 HL 59205), and the American Heart Association Northland Postdoctoral Fellowship Award. Submitted February 21, 2002; accepted July 11, 2002. Reprint requests: Véronique L. Roger, MD, MPH, Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905. Copyright 2003, Mosby, Inc. All rights reserved. 0002-8703/2003/$30.00 + 0 doi:10.1067/mhj.2003.187
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Background: Studies have reported that a large proportion of the cases of congestive heart failure (CHF) with mixed etiologies have preserved left ventricular systolic function. Whether this is the case in subjects with CHF after myocardial infarction (MI) is not known. This study was undertaken to examine the prevalence and characteristics associated with CHF in patients who had preserved ejection fraction (LVEF) after MI. Methods: Clinical characteristics and LVEF were ascertained in a population-based cohort of patients with CHF after incident MI in Olmsted County, Minn. All MIs were validated by use of standardized epidemiological criteria, and all episodes of CHF were validated by use of Framingham criteria. Results: Between 1979 and 1994, 1658 patients had an MI, and 644 of these patients (38%) had CHF during 7.4 ± 5.4 years of follow-up. Of these patients, 395 (61%) underwent LVEF assessment. Preserved LVEF (ie, ≥50%) was present in 30% of cases, and this proportion did not change with time. The proportion of women with CHF and preserved LVEF (37%) was greater than the proportion of men (23%, P = .002). The positive association between female sex and preserved LVEF remained significant after adjustment (odds ratio 1.97, 95% Cl 1.26-3.07, P = .003). The highest tertile of peak creatinine phosphokinase level was negatively associated with preserved LVEF (odds ratio 0.51, 95% Cl 0.29-0.89). Conclusion: A notable proportion of cases of CHF after MI have preserved LVEF. This underscores the burden of CHF with preserved LVEF in a well-defined group of patients with documented coronary disease. CHF with preserved LVEF after MI is associated with female sex and smaller MI size.
AB - Background: Studies have reported that a large proportion of the cases of congestive heart failure (CHF) with mixed etiologies have preserved left ventricular systolic function. Whether this is the case in subjects with CHF after myocardial infarction (MI) is not known. This study was undertaken to examine the prevalence and characteristics associated with CHF in patients who had preserved ejection fraction (LVEF) after MI. Methods: Clinical characteristics and LVEF were ascertained in a population-based cohort of patients with CHF after incident MI in Olmsted County, Minn. All MIs were validated by use of standardized epidemiological criteria, and all episodes of CHF were validated by use of Framingham criteria. Results: Between 1979 and 1994, 1658 patients had an MI, and 644 of these patients (38%) had CHF during 7.4 ± 5.4 years of follow-up. Of these patients, 395 (61%) underwent LVEF assessment. Preserved LVEF (ie, ≥50%) was present in 30% of cases, and this proportion did not change with time. The proportion of women with CHF and preserved LVEF (37%) was greater than the proportion of men (23%, P = .002). The positive association between female sex and preserved LVEF remained significant after adjustment (odds ratio 1.97, 95% Cl 1.26-3.07, P = .003). The highest tertile of peak creatinine phosphokinase level was negatively associated with preserved LVEF (odds ratio 0.51, 95% Cl 0.29-0.89). Conclusion: A notable proportion of cases of CHF after MI have preserved LVEF. This underscores the burden of CHF with preserved LVEF in a well-defined group of patients with documented coronary disease. CHF with preserved LVEF after MI is associated with female sex and smaller MI size.
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U2 - 10.1067/mhj.2003.187
DO - 10.1067/mhj.2003.187
M3 - Article
C2 - 12679774
AN - SCOPUS:0345269974
SN - 0002-8703
VL - 145
SP - 742
EP - 748
JO - American heart journal
JF - American heart journal
IS - 4
ER -