Health-related quality of life in children and young adults with post-thrombotic syndrome: Results from a cross-sectional study

Riten Kumar, Vilmarie Rodriguez, Jane M S Matsumoto, Shakila P. Khan, Amy L. Weaver, Robert D. Mcbane, Timothy J. Beebe, John A. Heit

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: While post-thrombotic syndrome (PTS) is increasingly recognized in children with a history of deep vein thrombosis (DVT), its impact on the health-related quality of life (HRQoL) is unknown. Our objective was to evaluate the association between the PTS and HRQoL by surveying a cohort of patients treated at our institution for DVT. Materials/Methods: All unique pediatric patients (0-18 years) treated for a DVT at the Mayo Clinic during the 15-year period, 1995-2009 were identified. A previously validated PTS survey instrument and age appropriate Pediatric Quality of Life inventory, version 4 (PedsQL 4.0) were mailed to eligible patients. Linear regression models were fit to compare the HRQoL scores between PTS groups (none, mild, moderate/severe), after adjusting for the presence of potential covariates. Results: Of the 90 respondents, 65 (72%) reported signs and/or symptoms of PTS. Mean age (±SD) at DVT diagnosis and survey completion were 12.8 (±6.1) and 19.3 (±7.7) years, respectively. Self-report PedsQL 4.0 module was completed by 79 patients, and 34 guardians completed the parent-proxy module. Patients with moderate to severe PTS reported significantly worse total HRQoL score (mean±SD, 71.3±13.4) as compared to patients with mild PTS (84.8±14.2) and no PTS (83.4±14) (P=0.001). Conclusion: Moderate to severe PTS has a significant impact on self-reported HRQoL as measured using the generic PedsQL 4.0. Further research is warranted to develop a venous disease-specific quality of life measure for children with a history of DVT.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalPediatric Blood and Cancer
Volume61
Issue number3
DOIs
StatePublished - Mar 2014

Fingerprint

Young Adult
Cross-Sectional Studies
Quality of Life
Venous Thrombosis
Linear Models
Pediatrics
Proxy
Self Report
Signs and Symptoms
Equipment and Supplies
Research
Surveys and Questionnaires

Keywords

  • Post-thrombotic syndrome
  • Quality of life

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Kumar, R., Rodriguez, V., Matsumoto, J. M. S., Khan, S. P., Weaver, A. L., Mcbane, R. D., ... Heit, J. A. (2014). Health-related quality of life in children and young adults with post-thrombotic syndrome: Results from a cross-sectional study. Pediatric Blood and Cancer, 61(3), 546-551. https://doi.org/10.1002/pbc.24840

Health-related quality of life in children and young adults with post-thrombotic syndrome : Results from a cross-sectional study. / Kumar, Riten; Rodriguez, Vilmarie; Matsumoto, Jane M S; Khan, Shakila P.; Weaver, Amy L.; Mcbane, Robert D.; Beebe, Timothy J.; Heit, John A.

In: Pediatric Blood and Cancer, Vol. 61, No. 3, 03.2014, p. 546-551.

Research output: Contribution to journalArticle

Kumar, R, Rodriguez, V, Matsumoto, JMS, Khan, SP, Weaver, AL, Mcbane, RD, Beebe, TJ & Heit, JA 2014, 'Health-related quality of life in children and young adults with post-thrombotic syndrome: Results from a cross-sectional study', Pediatric Blood and Cancer, vol. 61, no. 3, pp. 546-551. https://doi.org/10.1002/pbc.24840
Kumar, Riten ; Rodriguez, Vilmarie ; Matsumoto, Jane M S ; Khan, Shakila P. ; Weaver, Amy L. ; Mcbane, Robert D. ; Beebe, Timothy J. ; Heit, John A. / Health-related quality of life in children and young adults with post-thrombotic syndrome : Results from a cross-sectional study. In: Pediatric Blood and Cancer. 2014 ; Vol. 61, No. 3. pp. 546-551.
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