Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

Chika R. Nwachukwu, Ryan S. Youland, Catherine Chioreso, Nicholas Wetjen, Amulya NageswaraRao, Gesina Keating, Nadia N Laack

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to assess the health-related quality of life (HRQOL) and the impact of treatment on HRQOL in long-term survivors of pediatric low-grade gliomas (LGGs) using an adult instrument. QOL of 121 patients with a diagnosis of LGG from the Mayo Clinic were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30 for cancer in general) and (EORTC QLQ-BN20 specific for brain tumors). Median follow-up was 21.9 years for the participants. Median age at diagnosis was 11.8 years and at assessment was 33 years. Mean (standard deviation) global QOL score for the study was 78 (18) and 76.4 (22.8) in a reference population of healthy adults. Using QLQ-C30, radiation treated patients compared to non-radiation patients reported lower physical functioning (p = 0.002), role functioning (p = 0.004), and more constipation problems (p < 0.001). Patients with tumor recurrence reported lower role functioning (p = 0.016), social functioning (p = 0.040), and more financial problems (p = 0.029) compared to their counterparts. Using QLQ-BN20, patients with deep tumors compared to cortical tumors reported more bladder control problems (p = 0.016). Radiation treated patients also reported more bladder control problems (p < 0.001) compared to their counterparts. In the multivariable analysis, radiation therapy remained an independent predictor of physical and role functioning as well as symptoms related to brain tumors like visual disorders and motor dysfunction. Global QOL of long-term survivors of pediatric LGGs is similar to that of a reference population of healthy adults. The following tumor and treatment related factors were most consistently associated with poorer QOL: CNS tumor location, post-operative radiation, and tumor recurrence. Future studies are necessary to identify strategies to improve QOL in this subgroup of patients.

Original languageEnglish (US)
Pages (from-to)599-607
Number of pages9
JournalJournal of Neuro-Oncology
Volume121
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Glioma
Survivors
Quality of Life
Pediatrics
Neoplasms
Radiation
Brain Neoplasms
Urinary Bladder
Recurrence
Vision Disorders
Constipation
Population
Radiotherapy
Therapeutics
Organizations
Research

Keywords

  • EORTC-QLQ-BN20
  • EORTC-QLQ-C30
  • Health-related quality of life
  • Low-grade gliomas
  • Pediatrics
  • Radiation therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs). / Nwachukwu, Chika R.; Youland, Ryan S.; Chioreso, Catherine; Wetjen, Nicholas; NageswaraRao, Amulya; Keating, Gesina; Laack, Nadia N.

In: Journal of Neuro-Oncology, Vol. 121, No. 3, 2014, p. 599-607.

Research output: Contribution to journalArticle

Nwachukwu, CR, Youland, RS, Chioreso, C, Wetjen, N, NageswaraRao, A, Keating, G & Laack, NN 2014, 'Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)', Journal of Neuro-Oncology, vol. 121, no. 3, pp. 599-607. https://doi.org/10.1007/s11060-014-1673-1
Nwachukwu, Chika R. ; Youland, Ryan S. ; Chioreso, Catherine ; Wetjen, Nicholas ; NageswaraRao, Amulya ; Keating, Gesina ; Laack, Nadia N. / Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs). In: Journal of Neuro-Oncology. 2014 ; Vol. 121, No. 3. pp. 599-607.
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