Einheilung vaskularisierter Knochenallotransplantate: Optimierung durch Kurzzeit-Immunsuppression und der empfängerbasierten Neovaskularisation

Translated title of the contribution: Healing of free vascularized bone allotransplants: Optimizing by short-term immunosuppression and host-derived neovascularization

G. A. Giessler, P. F. Friedrich, R. H. Shin, Allen Thorp Bishop

Research output: Contribution to journalArticle

Abstract

Background. Living bone allotransplants (ATs) currently require long-term immunosuppression (IS), but this is impractical for extremity-preserving procedures. An alternativemethod to maintain viability of the transplant uses host-derived neoangiogeneic vessels combined with short-term IS.Materials and Methods. Diaphyseal femoral defects in Dutch-Belted rabbits were reconstructed with a free microvascular AT from New Zealand White rabbits. Additionally, a host-derived intramedullary pedicled fascial flap was placed and short-term IS administered to two of four groups. Neovascularization and bone healing were quantified by microangiography and a custom radiographic score.Results. Bone ATs with perfused fascial flaps achieved bone healing equivalent to auto transplant controls, even when they received IS only until host-derived neoangiogenesis replaced the original perfusion. Vascularized ATs without this combination achieved signi-ficantly inferior results.Summary. This rabbit model demonstrated that increased bone turnover allows good healing but may temporarily weaken the allotransplant. However, by the more intense replacement of the graft with host-derived cells, this process may, in the long-term, ultimately result in a better transplant than an avascular graft.

Original languageGerman
Pages (from-to)479-486
Number of pages8
JournalUnfallchirurg
Volume112
Issue number5
DOIs
StatePublished - May 2009

Fingerprint

Immunosuppression
Transplants
Bone and Bones
Rabbits
Surgical Flaps
Bone Remodeling
Thigh
Extremities
Perfusion

Keywords

  • Allogenic bone
  • Immunosuppression
  • Microvascular transplantation
  • Rabbit model
  • Surgical neoangiogenesis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Emergency Medicine
  • Medicine(all)

Cite this

Einheilung vaskularisierter Knochenallotransplantate : Optimierung durch Kurzzeit-Immunsuppression und der empfängerbasierten Neovaskularisation. / Giessler, G. A.; Friedrich, P. F.; Shin, R. H.; Bishop, Allen Thorp.

In: Unfallchirurg, Vol. 112, No. 5, 05.2009, p. 479-486.

Research output: Contribution to journalArticle

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