Headache in organ transplant recipients

Todd Rozen, Eelco F M Wijdicks

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Objective: The goal of this article is to review causes and management of headache in patients who have received an organ transplant. Their possible mechanisms and specific treatment modalities were reviewed as well. Data Sources: Review of the literature for headache and organ transplantation. Study Selection: Medline search from 1966 through 1996; personal case on treatment refractory cyclosporine-associatod headache. Date Extraction: The studies included were critically evaluated by the two authors. Data Synthesis: The number of organ transplantations is rapidly increasing. Headache is a well-recognized complication of organ transplantation. The nature of the post transplant headache has been poorly classified, but also poorly understood. In the evaluation of the transplant patient with presenting headache, it is most practical to think in the manner of pharmacologic (immunosuppressive agents such as cyclospodne, FK506, and OKT3) versus nonpharmacologic (CNS infections, intracranial hematomas) precipitants of headache. Evaluation of transplant recipients with new onset headache should include medical and neurologic examinations, laboratory studies, and neuroimaging. In the vast majority of cases, cyclosporine can be implicated as the cause of the headache. Conclusion: Neurologic complications are common after transplantation and, surprisingly, headaches make up a large percentage of these disorders. Cyclosporine, FK506, and OKT3 have been well documented in the literature as triggers of headache, but only cyclosporine associated headaches have been characterized. Prospective studies on the frequency of headache in transplant recipients and its effects on quality of life are warranted.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalHeadache Quarterly
Volume8
Issue number3
StatePublished - Aug 19 1997

Fingerprint

Headache
Transplants
Cyclosporine
Organ Transplantation
Muromonab-CD3
Tacrolimus
Transplant Recipients
Information Storage and Retrieval
Neurologic Examination
Immunosuppressive Agents
Neuroimaging
Hematoma
Nervous System
Transplantation
Quality of Life
Prospective Studies

Keywords

  • Cyctosporine
  • FK506
  • Headache
  • Transplantation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Rozen, T., & Wijdicks, E. F. M. (1997). Headache in organ transplant recipients. Headache Quarterly, 8(3), 214-218.

Headache in organ transplant recipients. / Rozen, Todd; Wijdicks, Eelco F M.

In: Headache Quarterly, Vol. 8, No. 3, 19.08.1997, p. 214-218.

Research output: Contribution to journalReview article

Rozen, T & Wijdicks, EFM 1997, 'Headache in organ transplant recipients', Headache Quarterly, vol. 8, no. 3, pp. 214-218.
Rozen T, Wijdicks EFM. Headache in organ transplant recipients. Headache Quarterly. 1997 Aug 19;8(3):214-218.
Rozen, Todd ; Wijdicks, Eelco F M. / Headache in organ transplant recipients. In: Headache Quarterly. 1997 ; Vol. 8, No. 3. pp. 214-218.
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