Head-to-head comparison of oral contrast agents for cross-sectional enterography: Small bowel distention, timing, and side effects

Brett M. Young, Joel Garland Fletcher, Fargol Booya, Scott Paulsen, Jeff Fidler, C. Daniel Johnson, James Huprich, John Barlow, Andrew Trout

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

OBJECTIVE: To determine small bowel distention, scanning time, and side effects of commercially available oral contrast agents used in cross-sectional enterography. METHODS: Ten healthy volunteers ingested 2000 mL of water, methylcellulose, polyethylene glycol (PEG), or 1350 mL of low-concentration barium (LCB) followed by 500 mL water on different days. Magnetic resonance imaging occurred every 10 minutes from 30 to 90 minutes after ingestion. Small bowel distention was compared between time points and agents. Volunteers ranked side effects, drinking difficulty, and preference. RESULTS: By quantitative assessment, PEG and LCB distended small bowel loops better than water and methylcellulose (P < 0.0001). Time to optimal distention of the terminal ileum was from 51 to 72 minutes. Water and methylcellulose had the fewest side effects. Water was the most preferred contrast and PEG the least. CONCLUSIONS: Polyethylene glycol and LCB distend small bowel better than water and methylcellulose. Polyethylene glycol was the most difficult to drink and least preferred agent.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume32
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Contrast Media
Methylcellulose
Water
Barium
Ileum
Drinking
Volunteers
Healthy Volunteers
Eating
Magnetic Resonance Imaging

Keywords

  • Crohn disease
  • CT enterography
  • MR enterography
  • Oral contrast agents
  • Small bowel imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Head-to-head comparison of oral contrast agents for cross-sectional enterography : Small bowel distention, timing, and side effects. / Young, Brett M.; Fletcher, Joel Garland; Booya, Fargol; Paulsen, Scott; Fidler, Jeff; Johnson, C. Daniel; Huprich, James; Barlow, John; Trout, Andrew.

In: Journal of Computer Assisted Tomography, Vol. 32, No. 1, 01.2008, p. 32-38.

Research output: Contribution to journalArticle

Young, Brett M. ; Fletcher, Joel Garland ; Booya, Fargol ; Paulsen, Scott ; Fidler, Jeff ; Johnson, C. Daniel ; Huprich, James ; Barlow, John ; Trout, Andrew. / Head-to-head comparison of oral contrast agents for cross-sectional enterography : Small bowel distention, timing, and side effects. In: Journal of Computer Assisted Tomography. 2008 ; Vol. 32, No. 1. pp. 32-38.
@article{24d3bd1ec848416fb9ba0d2b693d2f72,
title = "Head-to-head comparison of oral contrast agents for cross-sectional enterography: Small bowel distention, timing, and side effects",
abstract = "OBJECTIVE: To determine small bowel distention, scanning time, and side effects of commercially available oral contrast agents used in cross-sectional enterography. METHODS: Ten healthy volunteers ingested 2000 mL of water, methylcellulose, polyethylene glycol (PEG), or 1350 mL of low-concentration barium (LCB) followed by 500 mL water on different days. Magnetic resonance imaging occurred every 10 minutes from 30 to 90 minutes after ingestion. Small bowel distention was compared between time points and agents. Volunteers ranked side effects, drinking difficulty, and preference. RESULTS: By quantitative assessment, PEG and LCB distended small bowel loops better than water and methylcellulose (P < 0.0001). Time to optimal distention of the terminal ileum was from 51 to 72 minutes. Water and methylcellulose had the fewest side effects. Water was the most preferred contrast and PEG the least. CONCLUSIONS: Polyethylene glycol and LCB distend small bowel better than water and methylcellulose. Polyethylene glycol was the most difficult to drink and least preferred agent.",
keywords = "Crohn disease, CT enterography, MR enterography, Oral contrast agents, Small bowel imaging",
author = "Young, {Brett M.} and Fletcher, {Joel Garland} and Fargol Booya and Scott Paulsen and Jeff Fidler and Johnson, {C. Daniel} and James Huprich and John Barlow and Andrew Trout",
year = "2008",
month = "1",
doi = "10.1097/RCT.0b013e318061961d",
language = "English (US)",
volume = "32",
pages = "32--38",
journal = "Journal of Computer Assisted Tomography",
issn = "0363-8715",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Head-to-head comparison of oral contrast agents for cross-sectional enterography

T2 - Small bowel distention, timing, and side effects

AU - Young, Brett M.

AU - Fletcher, Joel Garland

AU - Booya, Fargol

AU - Paulsen, Scott

AU - Fidler, Jeff

AU - Johnson, C. Daniel

AU - Huprich, James

AU - Barlow, John

AU - Trout, Andrew

PY - 2008/1

Y1 - 2008/1

N2 - OBJECTIVE: To determine small bowel distention, scanning time, and side effects of commercially available oral contrast agents used in cross-sectional enterography. METHODS: Ten healthy volunteers ingested 2000 mL of water, methylcellulose, polyethylene glycol (PEG), or 1350 mL of low-concentration barium (LCB) followed by 500 mL water on different days. Magnetic resonance imaging occurred every 10 minutes from 30 to 90 minutes after ingestion. Small bowel distention was compared between time points and agents. Volunteers ranked side effects, drinking difficulty, and preference. RESULTS: By quantitative assessment, PEG and LCB distended small bowel loops better than water and methylcellulose (P < 0.0001). Time to optimal distention of the terminal ileum was from 51 to 72 minutes. Water and methylcellulose had the fewest side effects. Water was the most preferred contrast and PEG the least. CONCLUSIONS: Polyethylene glycol and LCB distend small bowel better than water and methylcellulose. Polyethylene glycol was the most difficult to drink and least preferred agent.

AB - OBJECTIVE: To determine small bowel distention, scanning time, and side effects of commercially available oral contrast agents used in cross-sectional enterography. METHODS: Ten healthy volunteers ingested 2000 mL of water, methylcellulose, polyethylene glycol (PEG), or 1350 mL of low-concentration barium (LCB) followed by 500 mL water on different days. Magnetic resonance imaging occurred every 10 minutes from 30 to 90 minutes after ingestion. Small bowel distention was compared between time points and agents. Volunteers ranked side effects, drinking difficulty, and preference. RESULTS: By quantitative assessment, PEG and LCB distended small bowel loops better than water and methylcellulose (P < 0.0001). Time to optimal distention of the terminal ileum was from 51 to 72 minutes. Water and methylcellulose had the fewest side effects. Water was the most preferred contrast and PEG the least. CONCLUSIONS: Polyethylene glycol and LCB distend small bowel better than water and methylcellulose. Polyethylene glycol was the most difficult to drink and least preferred agent.

KW - Crohn disease

KW - CT enterography

KW - MR enterography

KW - Oral contrast agents

KW - Small bowel imaging

UR - http://www.scopus.com/inward/record.url?scp=39849108610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39849108610&partnerID=8YFLogxK

U2 - 10.1097/RCT.0b013e318061961d

DO - 10.1097/RCT.0b013e318061961d

M3 - Article

C2 - 18303285

AN - SCOPUS:39849108610

VL - 32

SP - 32

EP - 38

JO - Journal of Computer Assisted Tomography

JF - Journal of Computer Assisted Tomography

SN - 0363-8715

IS - 1

ER -