Head modeling and cortical source localization in epilepsy

Zeynep Akalin Acar, Scott Makeig, Gregory Alan Worrell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

In this study, we developed numerical methods for investigating the dynamics of epilepsy from multi-scale EEG recordings acquired simultaneously from the scalp (sEEG) and intracranial subdural and/or depth electrodes (iEEG) in patients undergoing pre-surgical evaluation at the epilepsy center of the Mayo Clinic (Rochester, MN). The data are analyzed using independent component analysis (ICA), which identifies and isolates independent signal components from multi-channel recordings. A realistic individual head model was constructed for a patient undergoing pre-surgical evaluation. The forward problem of electro-magnetic source localization was solved using the Boundary Element Method (BEM). Using this approach, we investigated the relationships between noninvasive and invasive source localization of human electrical brain data sources. A difference of about 1 cm was observed between sources estimated from sEEG and iEEG measurements.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages3763-3766
Number of pages4
StatePublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

Fingerprint

Independent component analysis
Boundary element method
Electroencephalography
Epilepsy
Brain
Numerical methods
Head
Insulator Elements
Electrodes
Information Storage and Retrieval
Scalp

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Acar, Z. A., Makeig, S., & Worrell, G. A. (2008). Head modeling and cortical source localization in epilepsy. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 3763-3766). [4650027]

Head modeling and cortical source localization in epilepsy. / Acar, Zeynep Akalin; Makeig, Scott; Worrell, Gregory Alan.

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 3763-3766 4650027.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Acar, ZA, Makeig, S & Worrell, GA 2008, Head modeling and cortical source localization in epilepsy. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"., 4650027, pp. 3763-3766, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, Canada, 8/20/08.
Acar ZA, Makeig S, Worrell GA. Head modeling and cortical source localization in epilepsy. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 3763-3766. 4650027
Acar, Zeynep Akalin ; Makeig, Scott ; Worrell, Gregory Alan. / Head modeling and cortical source localization in epilepsy. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. pp. 3763-3766
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