Head and neck neoplasms: Magnetization transfer analysis

David M. Yousem, Kathleen T. Montone, Lisa M. Sheppard, Vijay M. Rao, Gregory S. Weinstein, Richard E Hayden

Research output: Contribution to journalArticle

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Abstract

PURPOSE: Magnetization transfer (MT) imaging enables analysis of the contribution of restricted motion protons in the macromolecular pool to magnetic resonance (MR) signal intensity. The authors undertook this study to determine whether MT ratios (MTRs) could be used to predict pathologic characteristics of head and neck neoplasms. MATERIALS AND METHODS: Fifty- four patients with pathologically proved neoplasms (squamous cell carcinomas, n = 33; non-squamous cell carcinomas, n = 11; benign masses, n = 10) underwent MT imaging. MTRs were correlated with pathologic findings. RESULTS: No statistically significant correlations were noted between MTRs and degree of differentiation, keratinization, cells per high-power field, and rate of mitosis. Statistically significant differences were found between MTRs of malignancies and muscle (P < .01), cerebrospinal fluid (P < .001), fat (P < .001), and benign neoplasms (P < .001). MTRs of muscle were higher than those of benign, squamous cell, and non-squamous cell neoplasms. CONCLUSION: MT imaging shows promise in differentiation of benign from malignant head and neck neoplasms. No statistically significant differences in MTRs were noted among malignancies.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
JournalRadiology
Volume192
Issue number3
StatePublished - Sep 1994
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Neoplasms
Muscles
Mitosis
Cerebrospinal Fluid
Protons
Cell Differentiation
Squamous Cell Carcinoma
Magnetic Resonance Spectroscopy
Epithelial Cells
Fats
Carcinoma

Keywords

  • Head and neck neoplasms, diagnosis
  • Head and neck neoplasms, MR
  • Magnetic resonance (MR), magnetization transfer contrast

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Yousem, D. M., Montone, K. T., Sheppard, L. M., Rao, V. M., Weinstein, G. S., & Hayden, R. E. (1994). Head and neck neoplasms: Magnetization transfer analysis. Radiology, 192(3), 703-707.

Head and neck neoplasms : Magnetization transfer analysis. / Yousem, David M.; Montone, Kathleen T.; Sheppard, Lisa M.; Rao, Vijay M.; Weinstein, Gregory S.; Hayden, Richard E.

In: Radiology, Vol. 192, No. 3, 09.1994, p. 703-707.

Research output: Contribution to journalArticle

Yousem, DM, Montone, KT, Sheppard, LM, Rao, VM, Weinstein, GS & Hayden, RE 1994, 'Head and neck neoplasms: Magnetization transfer analysis', Radiology, vol. 192, no. 3, pp. 703-707.
Yousem DM, Montone KT, Sheppard LM, Rao VM, Weinstein GS, Hayden RE. Head and neck neoplasms: Magnetization transfer analysis. Radiology. 1994 Sep;192(3):703-707.
Yousem, David M. ; Montone, Kathleen T. ; Sheppard, Lisa M. ; Rao, Vijay M. ; Weinstein, Gregory S. ; Hayden, Richard E. / Head and neck neoplasms : Magnetization transfer analysis. In: Radiology. 1994 ; Vol. 192, No. 3. pp. 703-707.
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