HCV recurrence in HIV-infected patients after liver Transplant

Christopher B. Hughes, Rolland Dickson, Murli Krishna, Darrin L. Willingham, Raj Satyanarayana, Denise Harnois, Andrew P. Keaveny, Barry Rosser, Jaime Aranda-Michel, David J. Kramer, Walter Hellinger, Julio C Mendez

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients coinfected with hepatitis C virus (HCV) and HIV undergoing liver transplantation (LT) are at risk of early, aggressive HCV recurrence. This study investigates the use of frequent protocol-driven biopsies to identify HCV recurrence post LT in coinfected patients. Five consecutive HIV/HCV-coinfected patients underwent LT. Liver biopsies were obtained post LT at 1 hour; days 7, 120, and 365; then annually; and as clinically indicated. Stage 2 (Ishak) or higher fibrosis occurred in 4 of the 5 patients by 60, 120, 270, and 365 days. Two patients died of HCV recurrence and liver failure at 6 and 35 months post LT. Three patients survived more than 4 years after LT, 2 having sustained virologic responses to anti-HCV treatment. Another has histologic recurrence not responding to treatment. Hepatitis C virus recurrence can be rapid and aggressive after LT in HIV-coinfected patients. Serial biopsies identify recurrence early, allowing for prompt initiation of treatment.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalJournal of the International Association of Physicians in AIDS Care
Volume9
Issue number2
DOIs
StatePublished - Mar 2010

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Hepacivirus
Liver Transplantation
HIV
Transplants
Recurrence
Liver
Biopsy
Liver Failure
Fibrosis
Therapeutics

Keywords

  • Hepatitis C virus
  • HIV/AIDS
  • Ishak score
  • Liver transplantation
  • Pegylated interferon

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

Cite this

HCV recurrence in HIV-infected patients after liver Transplant. / Hughes, Christopher B.; Dickson, Rolland; Krishna, Murli; Willingham, Darrin L.; Satyanarayana, Raj; Harnois, Denise; Keaveny, Andrew P.; Rosser, Barry; Aranda-Michel, Jaime; Kramer, David J.; Hellinger, Walter; Mendez, Julio C.

In: Journal of the International Association of Physicians in AIDS Care, Vol. 9, No. 2, 03.2010, p. 87-93.

Research output: Contribution to journalArticle

Hughes, CB, Dickson, R, Krishna, M, Willingham, DL, Satyanarayana, R, Harnois, D, Keaveny, AP, Rosser, B, Aranda-Michel, J, Kramer, DJ, Hellinger, W & Mendez, JC 2010, 'HCV recurrence in HIV-infected patients after liver Transplant', Journal of the International Association of Physicians in AIDS Care, vol. 9, no. 2, pp. 87-93. https://doi.org/10.1177/1545109710362592
Hughes, Christopher B. ; Dickson, Rolland ; Krishna, Murli ; Willingham, Darrin L. ; Satyanarayana, Raj ; Harnois, Denise ; Keaveny, Andrew P. ; Rosser, Barry ; Aranda-Michel, Jaime ; Kramer, David J. ; Hellinger, Walter ; Mendez, Julio C. / HCV recurrence in HIV-infected patients after liver Transplant. In: Journal of the International Association of Physicians in AIDS Care. 2010 ; Vol. 9, No. 2. pp. 87-93.
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