Hb Silver Springs [β131(H9)Gln→His], a new hemoglobin variant found in six African-Americans

J. D. Hoyer, M. J. Wick, S. N. Thibodeau, K. S. Kechteiger, J. D. Cook, V. F. Fairbanks

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Abstract

We report a new hemoglobin variant which we have named Hb Silver Springs. This variant results from a substitution CAG→CAC (Gln→His) at codon 131 of the β chain. It was detected only by cation exchange high performance liquid chromatography. This is the fifth reported substitution at codon 131. This variant does not appear to have any clinical or hematologic manifestations.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalHemoglobin
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1998

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ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

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