Hb S/Hb Lepore with mild sickling symptoms: A hemoglobin variant with mostly δ-chain sequences ameliorates sickle-cell disease

V. F. Fairbanks, D. J. McCormick, K. S. Kubik, W. N. Rezuke, D. Black, M. S. Ochaney, D. Schwartz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a nonα-chain variant with a high proportion of δ chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A2 may be beneficial in sickle-cell disease.

Original languageEnglish (US)
Pages (from-to)164-165
Number of pages2
JournalAmerican journal of hematology
Volume54
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Hb A
  • Hb Lepore
  • Hb S
  • delta chain
  • sickle-cell disease

ASJC Scopus subject areas

  • Hematology

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