Approximately 700 hemoglobin variants have been reported, causing a variety of clinical manifestations, with the majority being clinically silent. We report a new hemoglobin variant, Hb Cook, that was found in combination with Hb E in a child of Thai origin. DNA sequencing of the β- globin gene showed that the mutation is AAA→ACA in codon 132, corresponding to β132 (H10)Lys→Thr.
|Original language||English (US)|
|Number of pages||6|
|State||Published - 1996|
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