Hb Cook [β132(H10)Lys→Thr]: A new hemoglobin variant in a southeast Asian family

P. J. Hutt, V. F. Fairbanks, T. C. Griffin, S. N. Thibodeau, M. M. Green, J. D. Hoyer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Approximately 700 hemoglobin variants have been reported, causing a variety of clinical manifestations, with the majority being clinically silent. We report a new hemoglobin variant, Hb Cook, that was found in combination with Hb E in a child of Thai origin. DNA sequencing of the β- globin gene showed that the mutation is AAA→ACA in codon 132, corresponding to β132 (H10)Lys→Thr.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
Issue number4
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical


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