Hb Cook [β132(H10)Lys→Thr]: A new hemoglobin variant in a southeast Asian family

P. J. Hutt, V. F. Fairbanks, T. C. Griffin, Stephen N Thibodeau, M. M. Green, James Hoyer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Approximately 700 hemoglobin variants have been reported, causing a variety of clinical manifestations, with the majority being clinically silent. We report a new hemoglobin variant, Hb Cook, that was found in combination with Hb E in a child of Thai origin. DNA sequencing of the β- globin gene showed that the mutation is AAA→ACA in codon 132, corresponding to β132 (H10)Lys→Thr.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalHemoglobin
Volume20
Issue number4
StatePublished - 1996

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Hemoglobins
Globins
DNA Sequence Analysis
Codon
Genes
Mutation
DNA
hemoglobin Cook

ASJC Scopus subject areas

  • Hematology
  • Biochemistry

Cite this

Hutt, P. J., Fairbanks, V. F., Griffin, T. C., Thibodeau, S. N., Green, M. M., & Hoyer, J. (1996). Hb Cook [β132(H10)Lys→Thr]: A new hemoglobin variant in a southeast Asian family. Hemoglobin, 20(4), 371-376.

Hb Cook [β132(H10)Lys→Thr] : A new hemoglobin variant in a southeast Asian family. / Hutt, P. J.; Fairbanks, V. F.; Griffin, T. C.; Thibodeau, Stephen N; Green, M. M.; Hoyer, James.

In: Hemoglobin, Vol. 20, No. 4, 1996, p. 371-376.

Research output: Contribution to journalArticle

Hutt, PJ, Fairbanks, VF, Griffin, TC, Thibodeau, SN, Green, MM & Hoyer, J 1996, 'Hb Cook [β132(H10)Lys→Thr]: A new hemoglobin variant in a southeast Asian family', Hemoglobin, vol. 20, no. 4, pp. 371-376.
Hutt, P. J. ; Fairbanks, V. F. ; Griffin, T. C. ; Thibodeau, Stephen N ; Green, M. M. ; Hoyer, James. / Hb Cook [β132(H10)Lys→Thr] : A new hemoglobin variant in a southeast Asian family. In: Hemoglobin. 1996 ; Vol. 20, No. 4. pp. 371-376.
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