Hb Chile [β28(B10)Leu→Met]: An unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia

R. Hojas-Bernal, P. McNab-Martin, Virgil F. Fairbanks, M. W. Holmes, James Hoyer, Daniel J Mc Cormick, K. S. Kubik

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Among the causes of life-long cyanosis are congenital methemoglobinemia due to M hemoglobins, congenital methemogiobinemia due to methemoglobin reductase deficiency, a small number of low oxygen affinity hemoglobins, and a small number of unstable hemoglobins that spontaneously form methemoglobin in vivo at an accelerated rate. We report an unstable hemoglobin with these characteristics that was observed in a family of indigenous (native American) origin living near Santiago, Chile. This variant has the substitution β28(B10)Leu→Met, unambiguously corresponding to the DNA mutation of CTG→ATG in β-globin gene codon 28.

Original languageEnglish (US)
Pages (from-to)125-134
Number of pages10
JournalHemoglobin
Volume23
Issue number2
StatePublished - 1999

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Methemoglobinemia
Methylene Blue
Hemolytic Anemia
Sulfonamides
Hemoglobins
Hemoglobin M
Cytochrome-B(5) Reductase
Methemoglobin
Cyanosis
Globins
North American Indians
Chile
Codon
Substitution reactions
Genes
Oxygen
Mutation
DNA
hemoglobin Chile

ASJC Scopus subject areas

  • Biochemistry
  • Hematology

Cite this

Hb Chile [β28(B10)Leu→Met] : An unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia. / Hojas-Bernal, R.; McNab-Martin, P.; Fairbanks, Virgil F.; Holmes, M. W.; Hoyer, James; Mc Cormick, Daniel J; Kubik, K. S.

In: Hemoglobin, Vol. 23, No. 2, 1999, p. 125-134.

Research output: Contribution to journalArticle

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AU - Mc Cormick, Daniel J

AU - Kubik, K. S.

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