Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed?

Xingchang Wei, Charles R G Guttmann, Simon K. Warfield, Michael Eliasziw, Joseph Ross Mitchell

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Changes in mean magnetic resonance imaging (MRI)-derived measurements between patient groups are often used to determine outcomes in therapeutic trials and other longitudinal studies of multiple sclerosis (MS). However, in day-to-day clinical practice the changes within individual patients may also be of interest. In this paper, we estimated the measurement error of an automated brain tissue quantification algorithm and determined the thresholds for statistically significant change of MRI-derived T2 lesion volume and brain atrophy in individual patients. Twenty patients with MS were scanned twice within 30 min. Brain tissue volumes were measured using the computer algorithm. Brain atrophy was estimated by calculation of brain parenchymal fraction. The threshold of change between repeated scans that represented statistically significant change beyond measurement error with 95% certainty was 0.65 mL for T2 lesion burden and 0.0056 for brain parenchymal fraction. Changes in lesion burden and brain atrophy below these thresholds can be safely (with 95% certainty) explained by measurement variability alone. These values provide clinical neurologists with a useful reference to interpret MRI-derived measures in individual patients.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalMultiple Sclerosis
Volume10
Issue number4
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Multiple Sclerosis
Atrophy
Brain
Magnetic Resonance Imaging
Longitudinal Studies

Keywords

  • Brain atrophy
  • Computer-assisted
  • Image processing
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Wei, X., Guttmann, C. R. G., Warfield, S. K., Eliasziw, M., & Mitchell, J. R. (2004). Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed? Multiple Sclerosis, 10(4), 402-406. https://doi.org/10.1191/1352458504ms1061oa

Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed? / Wei, Xingchang; Guttmann, Charles R G; Warfield, Simon K.; Eliasziw, Michael; Mitchell, Joseph Ross.

In: Multiple Sclerosis, Vol. 10, No. 4, 08.2004, p. 402-406.

Research output: Contribution to journalArticle

Wei, X, Guttmann, CRG, Warfield, SK, Eliasziw, M & Mitchell, JR 2004, 'Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed?', Multiple Sclerosis, vol. 10, no. 4, pp. 402-406. https://doi.org/10.1191/1352458504ms1061oa
Wei, Xingchang ; Guttmann, Charles R G ; Warfield, Simon K. ; Eliasziw, Michael ; Mitchell, Joseph Ross. / Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed?. In: Multiple Sclerosis. 2004 ; Vol. 10, No. 4. pp. 402-406.
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