TY - JOUR
T1 - Harnessing the effects of endurance exercise to optimize cognitive health
T2 - Fundamental insights from Dr. Mark P. Mattson
AU - Jachim, Sarah K.
AU - Sakamoto, Ayumi E.
AU - Zhang, Xu
AU - Pearsall, Vesselina M.
AU - Schafer, Marissa J.
AU - LeBrasseur, Nathan K.
N1 - Funding Information:
The authors acknowledge the support of the National Institutes of Aging, National Institutes of HealthAG053832, AG044170 (NKL) and AG058798 (MJS). Moreover, the authors are grateful for the artwork of Sabrina Brady featured in Fig. 1.
Funding Information:
The authors acknowledge the support of the National Institutes of Aging , National Institutes of Health AG053832 , AG044170 (NKL) and AG058798 (MJS). Moreover, the authors are grateful for the artwork of Sabrina Brady featured in Fig. 1 .
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12
Y1 - 2020/12
N2 - Dr. Mark Mattson has had a highly productive and impactful tenure as a neuroscientist at the Intramural Research Program of the National Institute on Aging. He has made notable contributions to understanding the mechanisms by which energetic stress, imparted by behaviors such as physical activity and periods of fasting, promotes rejuvenation and resilience within brain regions critical for learning and memory. In honor of Dr. Mattson's work, this manuscript will highlight the fascinating mechanisms by which endurance exercise training conveys beneficial effects upon the structure and function of the nervous system; that is, by mediating the synthesis and secretion of factors that directly support brain homeostasis, including brain-derived neurotrophic factor, FNDC5/irisin, ketone bodies, growth factors, cathepsin B, serotonin, and 4-hydroxynonenal. The molecular and cellular effects of these factors are discussed herein. In the face of population aging and an overwhelming surge in the prevalence of Alzheimer's disease and related disorders, Dr. Mattson's work as a champion and role model for physically active lifestyles is more important than ever.
AB - Dr. Mark Mattson has had a highly productive and impactful tenure as a neuroscientist at the Intramural Research Program of the National Institute on Aging. He has made notable contributions to understanding the mechanisms by which energetic stress, imparted by behaviors such as physical activity and periods of fasting, promotes rejuvenation and resilience within brain regions critical for learning and memory. In honor of Dr. Mattson's work, this manuscript will highlight the fascinating mechanisms by which endurance exercise training conveys beneficial effects upon the structure and function of the nervous system; that is, by mediating the synthesis and secretion of factors that directly support brain homeostasis, including brain-derived neurotrophic factor, FNDC5/irisin, ketone bodies, growth factors, cathepsin B, serotonin, and 4-hydroxynonenal. The molecular and cellular effects of these factors are discussed herein. In the face of population aging and an overwhelming surge in the prevalence of Alzheimer's disease and related disorders, Dr. Mattson's work as a champion and role model for physically active lifestyles is more important than ever.
KW - Aging
KW - Alzheimer's disease
KW - Brain-derived neurotrophic factor
KW - Ketone bodies
KW - Neurogenesis
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U2 - 10.1016/j.arr.2020.101147
DO - 10.1016/j.arr.2020.101147
M3 - Review article
C2 - 32814127
AN - SCOPUS:85091610271
SN - 1568-1637
VL - 64
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 101147
ER -