Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Martina Bocchetta; Marina Boccardi; Rossana Ganzola; Liana G. Apostolova; Gregory Preboske; Dominik Wolf; Clarissa Ferrari; Patrizio Pasqualetti; Nicolas Robitaille; Simon Duchesne; Clifford R. Jack; Giovanni B. Frisoni; George Bartzokis; Charles Decarli; Leyla Detoledo-Morrell; Andreas Fellgiebel; Michael Firbank; Lotte Gerritsen; Wouter Henneman; Ronald J. Killiany; Nikolai Malykhin; Jens C. Pruessner; Hilkka Soininen; Lei Wang

doi:10.1016/j.jalz.2013.12.019

Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Martina Bocchetta, Marina Boccardi, Rossana Ganzola, Liana G. Apostolova, Gregory Preboske, Dominik Wolf, Clarissa Ferrari, Patrizio Pasqualetti, Nicolas Robitaille, Simon Duchesne, Clifford R. Jack, Giovanni B. Frisoni, George Bartzokis, Charles Decarli, Leyla Detoledo-Morrell, Andreas Fellgiebel, Michael Firbank, Lotte Gerritsen, Wouter Henneman, Ronald J. KillianyNikolai Malykhin, Jens C. Pruessner, Hilkka Soininen, Lei Wang

Radiology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Original language	English (US)
Pages (from-to)	151-160.e5
Journal	Alzheimer's and Dementia
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.jalz.2013.12.019
State	Published - 2015

Keywords

ADNI
Alzheimer's disease
Anatomic landmark
Harmonization
Harmonized protocol
Hippocampal atrophy
Hippocampal volume
Hippocampus
MRI
Manual tracing
Medial temporal lobes
Neuroimaging
Standard operating procedures

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

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10.1016/j.jalz.2013.12.019

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Bocchetta, M., Boccardi, M., Ganzola, R., Apostolova, L. G., Preboske, G., Wolf, D., Ferrari, C., Pasqualetti, P., Robitaille, N., Duchesne, S., Jack, C. R., Frisoni, G. B., Bartzokis, G., Decarli, C., Detoledo-Morrell, L., Fellgiebel, A., Firbank, M., Gerritsen, L., Henneman, W., ... Wang, L. (2015). Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project. Alzheimer's and Dementia, 11(2), 151-160.e5. https://doi.org/10.1016/j.jalz.2013.12.019

Bocchetta, M, Boccardi, M, Ganzola, R, Apostolova, LG, Preboske, G, Wolf, D, Ferrari, C, Pasqualetti, P, Robitaille, N, Duchesne, S, Jack, CR, Frisoni, GB, Bartzokis, G, Decarli, C, Detoledo-Morrell, L, Fellgiebel, A, Firbank, M, Gerritsen, L, Henneman, W, Killiany, RJ, Malykhin, N, Pruessner, JC, Soininen, H & Wang, L 2015, 'Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project', Alzheimer's and Dementia, vol. 11, no. 2, pp. 151-160.e5. https://doi.org/10.1016/j.jalz.2013.12.019

@article{9c19fc7aa2754e82ad837302cd91ef4a,

title = "Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project",

abstract = "Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.",

keywords = "ADNI, Alzheimer's disease, Anatomic landmark, Harmonization, Harmonized protocol, Hippocampal atrophy, Hippocampal volume, Hippocampus, MRI, Manual tracing, Medial temporal lobes, Neuroimaging, Standard operating procedures",

author = "Martina Bocchetta and Marina Boccardi and Rossana Ganzola and Apostolova, {Liana G.} and Gregory Preboske and Dominik Wolf and Clarissa Ferrari and Patrizio Pasqualetti and Nicolas Robitaille and Simon Duchesne and Jack, {Clifford R.} and Frisoni, {Giovanni B.} and George Bartzokis and Charles Decarli and Leyla Detoledo-Morrell and Andreas Fellgiebel and Michael Firbank and Lotte Gerritsen and Wouter Henneman and Killiany, {Ronald J.} and Nikolai Malykhin and Pruessner, {Jens C.} and Hilkka Soininen and Lei Wang",

year = "2015",

doi = "10.1016/j.jalz.2013.12.019",

language = "English (US)",

volume = "11",

pages = "151--160.e5",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Harmonized benchmark labels of the hippocampus on magnetic resonance

T2 - The EADC-ADNI project

AU - Bocchetta, Martina

AU - Boccardi, Marina

AU - Ganzola, Rossana

AU - Apostolova, Liana G.

AU - Preboske, Gregory

AU - Wolf, Dominik

AU - Ferrari, Clarissa

AU - Pasqualetti, Patrizio

AU - Robitaille, Nicolas

AU - Duchesne, Simon

AU - Jack, Clifford R.

AU - Frisoni, Giovanni B.

AU - Bartzokis, George

AU - Decarli, Charles

AU - Detoledo-Morrell, Leyla

AU - Fellgiebel, Andreas

AU - Firbank, Michael

AU - Gerritsen, Lotte

AU - Henneman, Wouter

AU - Killiany, Ronald J.

AU - Malykhin, Nikolai

AU - Pruessner, Jens C.

AU - Soininen, Hilkka

AU - Wang, Lei

PY - 2015

Y1 - 2015

N2 - Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

AB - Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

KW - ADNI

KW - Alzheimer's disease

KW - Anatomic landmark

KW - Harmonization

KW - Harmonized protocol

KW - Hippocampal atrophy

KW - Hippocampal volume

KW - Hippocampus

KW - MRI

KW - Manual tracing

KW - Medial temporal lobes

KW - Neuroimaging

KW - Standard operating procedures

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U2 - 10.1016/j.jalz.2013.12.019

DO - 10.1016/j.jalz.2013.12.019

M3 - Article

C2 - 25223727

AN - SCOPUS:84933674064

SN - 1552-5260

VL - 11

SP - 151-160.e5

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Abstract

Keywords

ASJC Scopus subject areas

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