Harmonized benchmark labels of the hippocampus on magnetic resonance

The EADC-ADNI project

Martina Bocchetta, Marina Boccardi, Rossana Ganzola, Liana G. Apostolova, Gregory Preboske, Dominik Wolf, Clarissa Ferrari, Patrizio Pasqualetti, Nicolas Robitaille, Simon Duchesne, Clifford R Jr. Jack, Giovanni B. Frisoni, George Bartzokis, Charles Decarli, Leyla Detoledo-Morrell, Andreas Fellgiebel, Michael Firbank, Lotte Gerritsen, Wouter Henneman, Ronald J. Killiany & 4 others Nikolai Malykhin, Jens C. Pruessner, Hilkka Soininen, Lei Wang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Original languageEnglish (US)
Pages (from-to)151-160.e5
JournalAlzheimer's and Dementia
Volume11
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Benchmarking
Neuroimaging
Hippocampus
Alzheimer Disease
Magnetic Resonance Spectroscopy
Confidence Intervals
Advisory Committees
Alzheimer Disease 10

Keywords

  • ADNI
  • Alzheimer's disease
  • Anatomic landmark
  • Harmonization
  • Harmonized protocol
  • Hippocampal atrophy
  • Hippocampal volume
  • Hippocampus
  • Manual tracing
  • Medial temporal lobes
  • MRI
  • Neuroimaging
  • Standard operating procedures

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Bocchetta, M., Boccardi, M., Ganzola, R., Apostolova, L. G., Preboske, G., Wolf, D., ... Wang, L. (2015). Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project. Alzheimer's and Dementia, 11(2), 151-160.e5. https://doi.org/10.1016/j.jalz.2013.12.019

Harmonized benchmark labels of the hippocampus on magnetic resonance : The EADC-ADNI project. / Bocchetta, Martina; Boccardi, Marina; Ganzola, Rossana; Apostolova, Liana G.; Preboske, Gregory; Wolf, Dominik; Ferrari, Clarissa; Pasqualetti, Patrizio; Robitaille, Nicolas; Duchesne, Simon; Jack, Clifford R Jr.; Frisoni, Giovanni B.; Bartzokis, George; Decarli, Charles; Detoledo-Morrell, Leyla; Fellgiebel, Andreas; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Killiany, Ronald J.; Malykhin, Nikolai; Pruessner, Jens C.; Soininen, Hilkka; Wang, Lei.

In: Alzheimer's and Dementia, Vol. 11, No. 2, 2015, p. 151-160.e5.

Research output: Contribution to journalArticle

Bocchetta, M, Boccardi, M, Ganzola, R, Apostolova, LG, Preboske, G, Wolf, D, Ferrari, C, Pasqualetti, P, Robitaille, N, Duchesne, S, Jack, CRJ, Frisoni, GB, Bartzokis, G, Decarli, C, Detoledo-Morrell, L, Fellgiebel, A, Firbank, M, Gerritsen, L, Henneman, W, Killiany, RJ, Malykhin, N, Pruessner, JC, Soininen, H & Wang, L 2015, 'Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project', Alzheimer's and Dementia, vol. 11, no. 2, pp. 151-160.e5. https://doi.org/10.1016/j.jalz.2013.12.019
Bocchetta, Martina ; Boccardi, Marina ; Ganzola, Rossana ; Apostolova, Liana G. ; Preboske, Gregory ; Wolf, Dominik ; Ferrari, Clarissa ; Pasqualetti, Patrizio ; Robitaille, Nicolas ; Duchesne, Simon ; Jack, Clifford R Jr. ; Frisoni, Giovanni B. ; Bartzokis, George ; Decarli, Charles ; Detoledo-Morrell, Leyla ; Fellgiebel, Andreas ; Firbank, Michael ; Gerritsen, Lotte ; Henneman, Wouter ; Killiany, Ronald J. ; Malykhin, Nikolai ; Pruessner, Jens C. ; Soininen, Hilkka ; Wang, Lei. / Harmonized benchmark labels of the hippocampus on magnetic resonance : The EADC-ADNI project. In: Alzheimer's and Dementia. 2015 ; Vol. 11, No. 2. pp. 151-160.e5.
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T1 - Harmonized benchmark labels of the hippocampus on magnetic resonance

T2 - The EADC-ADNI project

AU - Bocchetta, Martina

AU - Boccardi, Marina

AU - Ganzola, Rossana

AU - Apostolova, Liana G.

AU - Preboske, Gregory

AU - Wolf, Dominik

AU - Ferrari, Clarissa

AU - Pasqualetti, Patrizio

AU - Robitaille, Nicolas

AU - Duchesne, Simon

AU - Jack, Clifford R Jr.

AU - Frisoni, Giovanni B.

AU - Bartzokis, George

AU - Decarli, Charles

AU - Detoledo-Morrell, Leyla

AU - Fellgiebel, Andreas

AU - Firbank, Michael

AU - Gerritsen, Lotte

AU - Henneman, Wouter

AU - Killiany, Ronald J.

AU - Malykhin, Nikolai

AU - Pruessner, Jens C.

AU - Soininen, Hilkka

AU - Wang, Lei

PY - 2015

Y1 - 2015

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