Harmonization of magnetic resonance-based manual hippocampal segmentation: A mandatory step for wide clinical use

Giovanni B. Frisoni, Clifford R. Jack

Research output: Contribution to journalEditorial

76 Scopus citations

Abstract

Hippocampal atrophy is a marker of disease state and progression in Alzheimer's disease. The gold standard to measure hippocampal volume is through manual segmentation. A number of protocols to measure hippocampal volume through manual segmentation have been developed, but the marked heterogeneity of anatomical landmarks has given rise to wide variability of volume estimates. With the aim of fostering the use of hippocampal volume in routine clinical settings, an international task force is currently working on developing a harmonized protocol that will resolve and reduce the present heterogeneity. The task force will then validate the harmonized protocol, develop harmonized probabilistic hippocampal maps, and develop illustrative and educational material on the use of the harmonized protocol and maps.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalAlzheimer's and Dementia
Volume7
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • Alzheimer's disease
  • Clinical trials
  • Early diagnosis
  • Hippocampal volumetry
  • MR imaging
  • Outcome measures

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

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