Hamster-adapted sin nombre virus causes disseminated infection and efficiently replicates in pulmonary endothelial cells without signs of disease

David Safronetz, Joseph Prescott, Elaine Haddock, Dana P. Scott, Heinz Feldmann, Hideki Ebihara

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

To date, a laboratory animal model for the study of Sin Nombre virus (SNV) infection or associated disease has not been described. Unlike infection with Andes virus, which causes lethal hantavirus pulmonary syndrome (HPS)-like disease in hamsters, SNV infection is short-lived, with no viremia and little dissemination. Here we investigated the effect of passaging SNV in hamsters. We found that a host-adapted SNV achieves prolonged and disseminated infection in hamsters, including efficient replication in pulmonary endothelial cells, albeit without signs of disease.

Original languageEnglish (US)
Pages (from-to)4778-4782
Number of pages5
JournalJournal of virology
Volume87
Issue number8
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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