Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells

Paul A. Fredrickson, Elliott Richelson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Hallucinogens were competitive antagonists of histamine at the H1-receptor of cultured mouse neuroblastoma cells. Their rank order of potency at this receptor was similar to that for their potency at eliciting subjective effects in vivo. Comparison with studies of other receptors, however, suggests that no single model of drug-receptor interaction adequately accounts for the known subjective effects of these compounds.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - Jun 15 1979


  • Cyclic GMP
  • H-receptor
  • Hallucinogen
  • Histamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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