Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells

Paul A. Fredrickson, Elliott Richelson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hallucinogens were competitive antagonists of histamine at the H1-receptor of cultured mouse neuroblastoma cells. Their rank order of potency at this receptor was similar to that for their potency at eliciting subjective effects in vivo. Comparison with studies of other receptors, however, suggests that no single model of drug-receptor interaction adequately accounts for the known subjective effects of these compounds.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalEuropean Journal of Pharmacology
Volume56
Issue number3
DOIs
StatePublished - Jun 15 1979

Fingerprint

Histamine H1 Antagonists
Hallucinogens
Drug Receptors
Histamine H1 Receptors
Neuroblastoma
Drug Interactions

Keywords

  • Cyclic GMP
  • H-receptor
  • Hallucinogen
  • Histamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells. / Fredrickson, Paul A.; Richelson, Elliott.

In: European Journal of Pharmacology, Vol. 56, No. 3, 15.06.1979, p. 260-264.

Research output: Contribution to journalArticle

Fredrickson, Paul A. ; Richelson, Elliott. / Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells. In: European Journal of Pharmacology. 1979 ; Vol. 56, No. 3. pp. 260-264.
@article{f4d25272e77d4654a812a959ee800be6,
title = "Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells",
abstract = "Hallucinogens were competitive antagonists of histamine at the H1-receptor of cultured mouse neuroblastoma cells. Their rank order of potency at this receptor was similar to that for their potency at eliciting subjective effects in vivo. Comparison with studies of other receptors, however, suggests that no single model of drug-receptor interaction adequately accounts for the known subjective effects of these compounds.",
keywords = "Cyclic GMP, H-receptor, Hallucinogen, Histamine",
author = "Fredrickson, {Paul A.} and Elliott Richelson",
year = "1979",
month = "6",
day = "15",
doi = "10.1016/0014-2999(79)90180-8",
language = "English (US)",
volume = "56",
pages = "260--264",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells

AU - Fredrickson, Paul A.

AU - Richelson, Elliott

PY - 1979/6/15

Y1 - 1979/6/15

N2 - Hallucinogens were competitive antagonists of histamine at the H1-receptor of cultured mouse neuroblastoma cells. Their rank order of potency at this receptor was similar to that for their potency at eliciting subjective effects in vivo. Comparison with studies of other receptors, however, suggests that no single model of drug-receptor interaction adequately accounts for the known subjective effects of these compounds.

AB - Hallucinogens were competitive antagonists of histamine at the H1-receptor of cultured mouse neuroblastoma cells. Their rank order of potency at this receptor was similar to that for their potency at eliciting subjective effects in vivo. Comparison with studies of other receptors, however, suggests that no single model of drug-receptor interaction adequately accounts for the known subjective effects of these compounds.

KW - Cyclic GMP

KW - H-receptor

KW - Hallucinogen

KW - Histamine

UR - http://www.scopus.com/inward/record.url?scp=0018365938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018365938&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(79)90180-8

DO - 10.1016/0014-2999(79)90180-8

M3 - Article

VL - 56

SP - 260

EP - 264

JO - European Journal of Pharmacology

T2 - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 3

ER -