Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma

Lindsay M. Morton, Leslie Bernstein, Sophia S. Wang, David W. Hein, Nathaniel Rothman, Joanne S. Colt, Scott Davis, James R Cerhan, Richard K. Severson, Robert Welch, Patricia Hartge, Shelia Hoar Zahm

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Abstract

Background: Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed. Methods: We examined NHL risk in relation to reported hair dyeuse among 1321 cases and 1057 controls from a US population-based multi-center study. DNA was extracted from blood or buccal cells to identify genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), which encode enzymes that metabolize aromatic amine compounds found in hair dyes. Results: Among women, 509 cases and 413 controls reported hair dye use [odds ratio (OR) = 1.2; 95% confidence interval (95% CI) = 0.9, 1.6]. Risk estimates were higher for use before 1980 than for use in 1980 or later, particularly for use of permanent, intense tone (black, dark brown, dark blonde) products (<1980-OR = 1.6; 95% CI 0.9, 2.7; ≥1980-OR = 0.6; 95% CI 0.4, 1.1). Risk estimates were increased for women who used permanent, intense tone products before 1980 if they had the rapid/intermediate NAT2 phenotype (OR = 3.3; 95% CI 1.3, 8.6) or the NAT1*10 allele (OR = 2.5; 95% CI 0.9, 7.6), but not if they were slow NAT2 acetylators (OR = 1.5; 95% CI 0.6, 3.6) or had no copies of the NAT1*10 allele (OR = 1.5; 95% CI 0.7, 3.3). NHL risk was not increased among women who began hair dye use after 1980 or among men. Conclusion: Our results support previous research demonstrating elevated NHL risk among women who used dark color or intense tone permanent hair dyes before 1980. We present the first evidence suggesting that this risk may differ by genetic variation in NAT1 and NAT2.

Original languageEnglish (US)
Pages (from-to)1759-1764
Number of pages6
JournalCarcinogenesis
Volume28
Issue number8
DOIs
StatePublished - Aug 2007

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Hair Dyes
Non-Hodgkin's Lymphoma
Odds Ratio
Confidence Intervals
Color
Alleles
Cheek
N-acetyltransferase 1
Hair
Amines
Phenotype
DNA
Enzymes

ASJC Scopus subject areas

  • Cancer Research

Cite this

Morton, L. M., Bernstein, L., Wang, S. S., Hein, D. W., Rothman, N., Colt, J. S., ... Zahm, S. H. (2007). Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma. Carcinogenesis, 28(8), 1759-1764. https://doi.org/10.1093/carcin/bgm121

Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma. / Morton, Lindsay M.; Bernstein, Leslie; Wang, Sophia S.; Hein, David W.; Rothman, Nathaniel; Colt, Joanne S.; Davis, Scott; Cerhan, James R; Severson, Richard K.; Welch, Robert; Hartge, Patricia; Zahm, Shelia Hoar.

In: Carcinogenesis, Vol. 28, No. 8, 08.2007, p. 1759-1764.

Research output: Contribution to journalArticle

Morton, LM, Bernstein, L, Wang, SS, Hein, DW, Rothman, N, Colt, JS, Davis, S, Cerhan, JR, Severson, RK, Welch, R, Hartge, P & Zahm, SH 2007, 'Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma', Carcinogenesis, vol. 28, no. 8, pp. 1759-1764. https://doi.org/10.1093/carcin/bgm121
Morton, Lindsay M. ; Bernstein, Leslie ; Wang, Sophia S. ; Hein, David W. ; Rothman, Nathaniel ; Colt, Joanne S. ; Davis, Scott ; Cerhan, James R ; Severson, Richard K. ; Welch, Robert ; Hartge, Patricia ; Zahm, Shelia Hoar. / Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma. In: Carcinogenesis. 2007 ; Vol. 28, No. 8. pp. 1759-1764.
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abstract = "Background: Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed. Methods: We examined NHL risk in relation to reported hair dyeuse among 1321 cases and 1057 controls from a US population-based multi-center study. DNA was extracted from blood or buccal cells to identify genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), which encode enzymes that metabolize aromatic amine compounds found in hair dyes. Results: Among women, 509 cases and 413 controls reported hair dye use [odds ratio (OR) = 1.2; 95{\%} confidence interval (95{\%} CI) = 0.9, 1.6]. Risk estimates were higher for use before 1980 than for use in 1980 or later, particularly for use of permanent, intense tone (black, dark brown, dark blonde) products (<1980-OR = 1.6; 95{\%} CI 0.9, 2.7; ≥1980-OR = 0.6; 95{\%} CI 0.4, 1.1). Risk estimates were increased for women who used permanent, intense tone products before 1980 if they had the rapid/intermediate NAT2 phenotype (OR = 3.3; 95{\%} CI 1.3, 8.6) or the NAT1*10 allele (OR = 2.5; 95{\%} CI 0.9, 7.6), but not if they were slow NAT2 acetylators (OR = 1.5; 95{\%} CI 0.6, 3.6) or had no copies of the NAT1*10 allele (OR = 1.5; 95{\%} CI 0.7, 3.3). NHL risk was not increased among women who began hair dye use after 1980 or among men. Conclusion: Our results support previous research demonstrating elevated NHL risk among women who used dark color or intense tone permanent hair dyes before 1980. We present the first evidence suggesting that this risk may differ by genetic variation in NAT1 and NAT2.",
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AU - Bernstein, Leslie

AU - Wang, Sophia S.

AU - Hein, David W.

AU - Rothman, Nathaniel

AU - Colt, Joanne S.

AU - Davis, Scott

AU - Cerhan, James R

AU - Severson, Richard K.

AU - Welch, Robert

AU - Hartge, Patricia

AU - Zahm, Shelia Hoar

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N2 - Background: Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed. Methods: We examined NHL risk in relation to reported hair dyeuse among 1321 cases and 1057 controls from a US population-based multi-center study. DNA was extracted from blood or buccal cells to identify genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), which encode enzymes that metabolize aromatic amine compounds found in hair dyes. Results: Among women, 509 cases and 413 controls reported hair dye use [odds ratio (OR) = 1.2; 95% confidence interval (95% CI) = 0.9, 1.6]. Risk estimates were higher for use before 1980 than for use in 1980 or later, particularly for use of permanent, intense tone (black, dark brown, dark blonde) products (<1980-OR = 1.6; 95% CI 0.9, 2.7; ≥1980-OR = 0.6; 95% CI 0.4, 1.1). Risk estimates were increased for women who used permanent, intense tone products before 1980 if they had the rapid/intermediate NAT2 phenotype (OR = 3.3; 95% CI 1.3, 8.6) or the NAT1*10 allele (OR = 2.5; 95% CI 0.9, 7.6), but not if they were slow NAT2 acetylators (OR = 1.5; 95% CI 0.6, 3.6) or had no copies of the NAT1*10 allele (OR = 1.5; 95% CI 0.7, 3.3). NHL risk was not increased among women who began hair dye use after 1980 or among men. Conclusion: Our results support previous research demonstrating elevated NHL risk among women who used dark color or intense tone permanent hair dyes before 1980. We present the first evidence suggesting that this risk may differ by genetic variation in NAT1 and NAT2.

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