Haemodynamics and tissue specificity with isradipine

J. B. LESLIE

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The significant effects of isradipine in producing arterial vasodilatation and mild negative chronotropic effects without significant negative inotropic effects suggests that this agent should provide excellent antihypertensive efficacy in the treatment of perioperative hypertension. Isradipine may prove to be a safe antihypertensive treatment in patients with impaired ventricular function (cardiac failure), impaired myocardial perfusion (ischaemia), and in cases of selected conduction abnormalities or arrhythmias. The demonstration that its effects are limited to vascular resistance rather than vascular capacitance is an important distinguishing feature of isradipine compared with other antihypertensive agents. Finally, the potential application of this dihydropyridine calcium antagonist for cytoprotection and its effects on atherosclerosis remain exciting therapeutic prospects.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Volume37
DOIs
StatePublished - Sep 1993

Keywords

  • Antihypertensive treatment
  • calcium antagonists
  • cardiovascular effects
  • isradipine
  • tissue–specific effects

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Haemodynamics and tissue specificity with isradipine'. Together they form a unique fingerprint.

  • Cite this