Haemodynamics and tissue specificity with isradipine

J. B. LESLIE

doi:10.1111/j.1399-6576.1993.tb03822.x

Haemodynamics and tissue specificity with isradipine

J. B. LESLIE

Anesthesiology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The significant effects of isradipine in producing arterial vasodilatation and mild negative chronotropic effects without significant negative inotropic effects suggests that this agent should provide excellent antihypertensive efficacy in the treatment of perioperative hypertension. Isradipine may prove to be a safe antihypertensive treatment in patients with impaired ventricular function (cardiac failure), impaired myocardial perfusion (ischaemia), and in cases of selected conduction abnormalities or arrhythmias. The demonstration that its effects are limited to vascular resistance rather than vascular capacitance is an important distinguishing feature of isradipine compared with other antihypertensive agents. Finally, the potential application of this dihydropyridine calcium antagonist for cytoprotection and its effects on atherosclerosis remain exciting therapeutic prospects.

Original language	English (US)
Pages (from-to)	33-37
Number of pages	5
Journal	Acta Anaesthesiologica Scandinavica
Volume	37
DOIs	https://doi.org/10.1111/j.1399-6576.1993.tb03822.x
State	Published - Sep 1993

Keywords

Antihypertensive treatment
calcium antagonists
cardiovascular effects
isradipine
tissue–specific effects

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1111/j.1399-6576.1993.tb03822.x

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KW - tissue–specific effects

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Haemodynamics and tissue specificity with isradipine

Abstract

Keywords

ASJC Scopus subject areas

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