H3K27M mutation in adult cerebellar glioblastoma

Victor M. Lu; Oluwaseun O. Akinduro; David J. Daniels

doi:10.1016/j.jocn.2019.11.016

H3K27M mutation in adult cerebellar glioblastoma

Victor M. Lu, Oluwaseun O. Akinduro, David J. Daniels

Neurosurgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

Original language	English (US)
Pages (from-to)	316-317
Number of pages	2
Journal	Journal of Clinical Neuroscience
Volume	71
DOIs	https://doi.org/10.1016/j.jocn.2019.11.016
State	Published - Jan 2020

Keywords

Adult
Cerebellum
Diffuse midline glioma
GBM
Glioblastoma
H3K27M

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

Access to Document

10.1016/j.jocn.2019.11.016

Cite this

@article{ea908306150541d289c5b39b490ef93b,

title = "H3K27M mutation in adult cerebellar glioblastoma",

abstract = "A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.",

keywords = "Adult, Cerebellum, Diffuse midline glioma, GBM, Glioblastoma, H3K27M",

author = "Lu, {Victor M.} and Akinduro, {Oluwaseun O.} and Daniels, {David J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = jan,

doi = "10.1016/j.jocn.2019.11.016",

language = "English (US)",

volume = "71",

pages = "316--317",

journal = "Journal of Clinical Neuroscience",

issn = "0967-5868",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - H3K27M mutation in adult cerebellar glioblastoma

AU - Lu, Victor M.

AU - Akinduro, Oluwaseun O.

AU - Daniels, David J.

PY - 2020/1

Y1 - 2020/1

N2 - A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

AB - A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

KW - Adult

KW - Cerebellum

KW - Diffuse midline glioma

KW - GBM

KW - Glioblastoma

KW - H3K27M

UR - http://www.scopus.com/inward/record.url?scp=85076568906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076568906&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2019.11.016

DO - 10.1016/j.jocn.2019.11.016

M3 - Article

C2 - 31843430

AN - SCOPUS:85076568906

SN - 0967-5868

VL - 71

SP - 316

EP - 317

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -

H3K27M mutation in adult cerebellar glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this