H3K27M mutation in adult cerebellar glioblastoma

Victor M. Lu, Oluwaseun O. Akinduro, David J. Daniels

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

Original languageEnglish (US)
JournalJournal of Clinical Neuroscience
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • Adult
  • Cerebellum
  • Diffuse midline glioma
  • GBM
  • Glioblastoma
  • H3K27M

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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