H3K27M mutation in adult cerebellar glioblastoma

Victor M. Lu; Oluwaseun O. Akinduro; David J. Daniels

doi:10.1016/j.jocn.2019.11.016

H3K27M mutation in adult cerebellar glioblastoma

Victor M. Lu, Oluwaseun O. Akinduro, David J. Daniels

Neurosurgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

Original language	English (US)
Journal	Journal of Clinical Neuroscience
DOIs	https://doi.org/10.1016/j.jocn.2019.11.016
State	Accepted/In press - Jan 1 2019

Keywords

Adult
Cerebellum
Diffuse midline glioma
GBM
Glioblastoma
H3K27M

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2019.11.016

Cite this

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title = "H3K27M mutation in adult cerebellar glioblastoma",

abstract = "A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.",

keywords = "Adult, Cerebellum, Diffuse midline glioma, GBM, Glioblastoma, H3K27M",

author = "Lu, {Victor M.} and Akinduro, {Oluwaseun O.} and Daniels, {David J.}",

year = "2019",

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doi = "10.1016/j.jocn.2019.11.016",

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T1 - H3K27M mutation in adult cerebellar glioblastoma

AU - Lu, Victor M.

AU - Akinduro, Oluwaseun O.

AU - Daniels, David J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

AB - A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.

KW - Adult

KW - Cerebellum

KW - Diffuse midline glioma

KW - GBM

KW - Glioblastoma

KW - H3K27M

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DO - 10.1016/j.jocn.2019.11.016

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SN - 0967-5868

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -

H3K27M mutation in adult cerebellar glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

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