H-Y antigen expression in patients with X-autosomal translocations and gonadal dysgenesis

F. P. Haseltine, V. A. Lynch, D. L. van Dyke, W. R. Breg, U. Francke

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cells from three patients with early gonadal failure and a balanced reciprocal translocation involving the long arm of the X chromosome and an autosome were studied. Fibroblasts from a patient with a similar balanced reciprocal translocation but normal reproductive capabilities were also studied. Two of the four patients were found to have serologically detectable H-Y antigen on their cells. Since H-Y antigen has been found on the cells of other patients with X chromosome abnormalities but without a Y chromosome, it is thought that the X chromosome plays a role in the regulation of H-Y antigen expression. This study suggests that the long arm of the X chromosome may be involved but the location of a regulatory gene cannot be identified in these results. These cases do not permit us to implicate H-Y antigen as a cause of gonadal dysgenesis and early gonadal failure in females who have structurally abnormal X chromosomes.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalAmerican Journal of Medical Genetics
Volume13
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

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H-Y Antigen
Gonadal Dysgenesis
X Chromosome
Y Chromosome
Regulator Genes
Chromosome Aberrations
Fibroblasts

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

H-Y antigen expression in patients with X-autosomal translocations and gonadal dysgenesis. / Haseltine, F. P.; Lynch, V. A.; van Dyke, D. L.; Breg, W. R.; Francke, U.

In: American Journal of Medical Genetics, Vol. 13, No. 2, 1982, p. 115-123.

Research output: Contribution to journalArticle

Haseltine, F. P. ; Lynch, V. A. ; van Dyke, D. L. ; Breg, W. R. ; Francke, U. / H-Y antigen expression in patients with X-autosomal translocations and gonadal dysgenesis. In: American Journal of Medical Genetics. 1982 ; Vol. 13, No. 2. pp. 115-123.
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