H-2Kb mutations limit the CTL response to SV40 TASA

S. Pan, P. J. Wettstein, B. B. Knowles

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The cytotoxic T lymphocyte (CTL) responses directed towards SV40 tumor-associated specific antigen (TASA) in nine strains of spontaneously arising Kb mutant mice were analyzed. All nine mutants generated normal levels of H-2Db-restricted response, but the K-end-restricted CTL response varied. B6.C-H-2bm1 (bm1) did not produce K-end-restricted SV40 TASA-specific CTL upon immunization, and SV40-transformed bm1 cells were not lysed by intra-H-2 recombinant Kb [B10.A(5R)] CTL. Nonreciprocal cross-reactive lysis was seen between B6-H-2bm8 (bm8) and B10.A(5R). Strain B6-H-2bm8 mice produce highly specific Kbm8-restricted CTL that lyse SV40-transformed bm8 cells (Kbm8SV) but not B10.A(5R) target cells (K5RSV), although Kbm8SV targets can be partially lysed by B10.A(5R) CTL. The other seven Kb mutants cross-react with B10.A(5R). These experiments definitively show that genes mapping to the K and/or D region directly control the H-2-restricted CTL response to SV40 TASA.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalJournal of Immunology
Volume128
Issue number1
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Pan, S., Wettstein, P. J., & Knowles, B. B. (1982). H-2Kb mutations limit the CTL response to SV40 TASA. Journal of Immunology, 128(1), 243-246.