Genes in the H-2 complex regulate the relative immunogenicity of the H-7.1 histocompatibility alloantigen, as measured by survival times of H-7.1-incompatible skin grafts in vivo. The gene controlling relative rejectability of H-7.1-incompatible grafts has been mapped to the H-2D region. H-7.1-incompatible skin grafts donated by H-2D(b) donors were rejected significantly more rapidly by H-2(a) H-2(b) heterozygous recipients than similar H-7.1-incompatible grafts donated by H-2D(d) donors. Further, there was absolutely no evidence of H-2 restriction in cytotoxic effector activity. In vivo cross-priming, as indicated by accelerated secondary graft rejection, was extensive. The efficiency of cross-priming was dependent upon the primary and secondary graft donor H-2 haplotypes.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Experimental Medicine|
|State||Published - 1977|
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