H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. I. Donor H-2D region control of H-7.1-immunogenicity and lack of restriction in vivo

P. J. Wettstein, G. Haughton, J. A. Frelinger

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Abstract

Genes in the H-2 complex regulate the relative immunogenicity of the H-7.1 histocompatibility alloantigen, as measured by survival times of H-7.1-incompatible skin grafts in vivo. The gene controlling relative rejectability of H-7.1-incompatible grafts has been mapped to the H-2D region. H-7.1-incompatible skin grafts donated by H-2D(b) donors were rejected significantly more rapidly by H-2(a) H-2(b) heterozygous recipients than similar H-7.1-incompatible grafts donated by H-2D(d) donors. Further, there was absolutely no evidence of H-2 restriction in cytotoxic effector activity. In vivo cross-priming, as indicated by accelerated secondary graft rejection, was extensive. The efficiency of cross-priming was dependent upon the primary and secondary graft donor H-2 haplotypes.

Original languageEnglish (US)
Pages (from-to)1346-1355
Number of pages10
JournalJournal of Experimental Medicine
Volume146
Issue number5
StatePublished - 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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