H-2 congenic strains of mice expressing the H-2(k), H-2(q) or H-2(f) haplotype were tested for their ability to expel Trichinella spiralis from the gut following infection with either 100, 150, 200, 400, 500, or 600 L1 infective larvae. H-2(q) and H-2(f) mice expelled worms more quickly than H-2(k) mice when 100-200 L1 larvae were given, but this H-2-controlled effect was much reduced when mice received 400 L1 larvae, and completely eliminated when 500 or 600 L1 larvae were given. The observed dose-dependent delay in the expulsion response was paralleled by a concurrent suppression of lymphocyte responsiveness. Lymphocytes from H-2(q) mice infected with 100-200 L1 larvae incorporated more [3H]thymidine than did cells from H-2(k) mice. However, this H-2-controlled difference was not apparent in cells from mice receiving 400-600 L1 larvae. The strongest proliferation response in each case was associated with mice infected with the smallest number of worms. Such strains of mice expressing H-2(q) or H-2(f) alleles were suppressed at high doses to a much greater extent than were mice expressing H-2(k), H-2 genes must influence this dose-dependent response. Many earlier studies, which failed to demonstrate marked H-2 effects on immunity to T. spiralis, employed infective doses which are shown here to preferentially suppressive to otherwise strains of mice.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Dec 1 1984|
ASJC Scopus subject areas
- Immunology and Allergy