Abstract
We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95% CI: 1.2-9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.
Original language | English (US) |
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Pages (from-to) | 153-157 |
Number of pages | 5 |
Journal | Journal of the neurological sciences |
Volume | 363 |
DOIs | |
State | Published - Apr 15 2016 |
Keywords
- 16S rRNA
- Cox regression
- Gut microbiota
- Kaplan-Meier
- Pediatric multiple sclerosis
- Relapse risk
- Survival analyses
ASJC Scopus subject areas
- Neurology
- Clinical Neurology