Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

Chelsea A. Vadnie, Jun Hyun Park, Noha Abdel Gawad, Ada Man Choi Ho, David J. Hinton, Doo Sup Choi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use disorders (AUD). In this review, we discuss the effects of several gut-brain peptides on alcohol-related behaviors and the potential mechanisms by which these gut-brain peptides may interfere with alcohol-induced changes in corticostriatal-limbic circuitry. This review provides a summary of current knowledge on gut-brain peptides focusing on five peptides: neurotensin, glucagon-like peptide 1, ghrelin, substance P, and neuropeptide Y. Our review will be helpful to develop novel therapeutic targets for AUD.

Original languageEnglish (US)
Article numberArticle 288
JournalFrontiers in Neuroscience
Volume8
Issue numberSEP
DOIs
StatePublished - 2014

Fingerprint

Alcohols
Peptides
Brain
Addictive Behavior
Neurotensin
Ghrelin
Glucagon-Like Peptide 1
Endocrine Cells
Neuropeptide Y
Appetite
Substance P
Energy Intake
Gastrointestinal Tract
Neurons
Therapeutics

Keywords

  • Alcohol
  • GLP-1
  • Neurotensin
  • NPY
  • peptide
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. / Vadnie, Chelsea A.; Park, Jun Hyun; Gawad, Noha Abdel; Ho, Ada Man Choi; Hinton, David J.; Choi, Doo Sup.

In: Frontiers in Neuroscience, Vol. 8, No. SEP, Article 288, 2014.

Research output: Contribution to journalArticle

Vadnie, Chelsea A. ; Park, Jun Hyun ; Gawad, Noha Abdel ; Ho, Ada Man Choi ; Hinton, David J. ; Choi, Doo Sup. / Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. In: Frontiers in Neuroscience. 2014 ; Vol. 8, No. SEP.
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