Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

Sid E. O'Bryant; Veer Gupta; Kim Henriksen; Melissa Edwards; Andreas Jeromin; Simone Lista; Chantal Bazenet; Holly Soares; Simon Lovestone; Harald Hampel; Thomas Montine; Kaj Blennow; Tatiana Foroud; Maria Carrillo; Neill Graff-Radford; Christoph Laske; Monique Breteler; Leslie Shaw; John Q. Trojanowski; Nicole Schupf; Robert A. Rissman; Anne M. Fagan; Pankaj Oberoi; Robert Umek; Michael W. Weiner; Paula Grammas; Holly Posner; Ralph Martins

doi:10.1016/j.jalz.2014.08.099

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

Sid E. O'Bryant, Veer Gupta, Kim Henriksen, Melissa Edwards, Andreas Jeromin, Simone Lista, Chantal Bazenet, Holly Soares, Simon Lovestone, Harald Hampel, Thomas Montine, Kaj Blennow, Tatiana Foroud, Maria Carrillo, Neill Graff-Radford, Christoph Laske, Monique Breteler, Leslie Shaw, John Q. Trojanowski, Nicole SchupfRobert A. Rissman, Anne M. Fagan, Pankaj Oberoi, Robert Umek, Michael W. Weiner, Paula Grammas, Holly Posner, Ralph Martins

Neurology

Research output: Contribution to journal › Review article › peer-review

118 Scopus citations

Abstract

The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field to foster cross-validation across cohorts and laboratories.

Original language	English (US)
Pages (from-to)	549-560
Number of pages	12
Journal	Alzheimer's and Dementia
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.jalz.2014.08.099
State	Published - May 1 2015

Keywords

Alzheimer's disease
Biomarkers
Blood
Dementia
Diagnosis
Plasma
Serum
Treatment

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2014.08.099

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O'Bryant, S. E., Gupta, V., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C., Soares, H., Lovestone, S., Hampel, H., Montine, T., Blennow, K., Foroud, T., Carrillo, M., Graff-Radford, N., Laske, C., Breteler, M., Shaw, L., Trojanowski, J. Q., ... Martins, R. (2015). Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's and Dementia, 11(5), 549-560. https://doi.org/10.1016/j.jalz.2014.08.099

O'Bryant, SE, Gupta, V, Henriksen, K, Edwards, M, Jeromin, A, Lista, S, Bazenet, C, Soares, H, Lovestone, S, Hampel, H, Montine, T, Blennow, K, Foroud, T, Carrillo, M, Graff-Radford, N, Laske, C, Breteler, M, Shaw, L, Trojanowski, JQ, Schupf, N, Rissman, RA, Fagan, AM, Oberoi, P, Umek, R, Weiner, MW, Grammas, P, Posner, H & Martins, R 2015, 'Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research', Alzheimer's and Dementia, vol. 11, no. 5, pp. 549-560. https://doi.org/10.1016/j.jalz.2014.08.099

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abstract = "The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field to foster cross-validation across cohorts and laboratories.",

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AU - O'Bryant, Sid E.

AU - Gupta, Veer

AU - Henriksen, Kim

AU - Edwards, Melissa

AU - Jeromin, Andreas

AU - Lista, Simone

AU - Bazenet, Chantal

AU - Soares, Holly

AU - Lovestone, Simon

AU - Hampel, Harald

AU - Montine, Thomas

AU - Blennow, Kaj

AU - Foroud, Tatiana

AU - Carrillo, Maria

AU - Graff-Radford, Neill

AU - Laske, Christoph

AU - Breteler, Monique

AU - Shaw, Leslie

AU - Trojanowski, John Q.

AU - Schupf, Nicole

AU - Rissman, Robert A.

AU - Fagan, Anne M.

AU - Oberoi, Pankaj

AU - Umek, Robert

AU - Weiner, Michael W.

AU - Grammas, Paula

AU - Posner, Holly

AU - Martins, Ralph

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Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

Abstract

Keywords

ASJC Scopus subject areas

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