Guidelines for prevention of NSAID-related ulcer complications

Frank L. Lanza, Francis K L Chan, Eamonn M M Quigley, John Inadomi, Darren Baroni, David Bernstein, William Brugge, Lin Chang, John Cunningham, Kleanthis G. Dendrinos, Kenneth DeVault, Steven Edmundowicz, Philip M. Ginsburg, Kelvin Hornbuckle, Costas Kefalas, Timothy Koch, Jenifer Lehrer, Anthony Lembo, John O'Brien, John PappHenry Parkman, Kumaravel S. Perumalsamy, Prasad G Iyer, Albert Roach, Richard Sampliner, Amnon Sonnenberg, John Vargo, Santhi Swaroop Vege, Marcelo Vela, Nizar Zein, Marc J. Zuckerman

Research output: Contribution to journalArticle

457 Citations (Scopus)

Abstract

Guidelines for clinical practice are intended to indicate preferred approaches to medical problems as established by scientifically valid research. Double-blind, placebo-controlled studies are preferable, but compassionate use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. Only when data that will not withstand objective scrutiny are available is a recommendation identified as a consensus of experts. Guidelines are applicable to all physicians who address the subject, without regard to specialty training or interests, and are intended to indicate the preferable, but not necessarily the only, acceptable approach to a specific problem. Guidelines are intended to be flexible and must be distinguished from standards of care, which are inflexible and rarely violated. Given the wide range of specifics in any health-care problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. These guidelines were developed under the auspices of the American College of Gastroenterology by a committee of experts in the field, reviewed by its Practice Parameters Committee, and approved by the Board of Trustees. The recommendations of these guidelines are therefore considered valid at the time of production based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at an established time and indicated at publication to assure continued validity. Owing to the volume of new data on the subject of non-steroidal anti-inflammatory drug (NSAID)-related injury to the upper gastrointestinal tract, i.e., the advent of cyclooxygenase (COX)-2 inhibitors, new data on interactions between these agents, as well as traditional NSAIDs, with aspirin and H. pylori, it was elected by the Committee to confine these guidelines to upper gastrointestinal (GI) injury and to leave post-duodenal injury as the subject of a separate guideline.

Original languageEnglish (US)
Pages (from-to)728-738
Number of pages11
JournalAmerican Journal of Gastroenterology
Volume104
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Ulcer
Anti-Inflammatory Agents
Guidelines
Pharmaceutical Preparations
Wounds and Injuries
Compassionate Use Trials
National Library of Medicine (U.S.)
Physicians
Trustees
Upper Gastrointestinal Tract
Cyclooxygenase 2 Inhibitors
Pylorus
Non-Steroidal Anti-Inflammatory Agents
Standard of Care
Practice Guidelines
Aspirin
Publications
Biomedical Research
Placebos
Delivery of Health Care

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lanza, F. L., Chan, F. K. L., Quigley, E. M. M., Inadomi, J., Baroni, D., Bernstein, D., ... Zuckerman, M. J. (2009). Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology, 104(3), 728-738. https://doi.org/10.1038/ajg.2009.115

Guidelines for prevention of NSAID-related ulcer complications. / Lanza, Frank L.; Chan, Francis K L; Quigley, Eamonn M M; Inadomi, John; Baroni, Darren; Bernstein, David; Brugge, William; Chang, Lin; Cunningham, John; Dendrinos, Kleanthis G.; DeVault, Kenneth; Edmundowicz, Steven; Ginsburg, Philip M.; Hornbuckle, Kelvin; Kefalas, Costas; Koch, Timothy; Lehrer, Jenifer; Lembo, Anthony; O'Brien, John; Papp, John; Parkman, Henry; Perumalsamy, Kumaravel S.; Iyer, Prasad G; Roach, Albert; Sampliner, Richard; Sonnenberg, Amnon; Vargo, John; Vege, Santhi Swaroop; Vela, Marcelo; Zein, Nizar; Zuckerman, Marc J.

In: American Journal of Gastroenterology, Vol. 104, No. 3, 03.2009, p. 728-738.

Research output: Contribution to journalArticle

Lanza, FL, Chan, FKL, Quigley, EMM, Inadomi, J, Baroni, D, Bernstein, D, Brugge, W, Chang, L, Cunningham, J, Dendrinos, KG, DeVault, K, Edmundowicz, S, Ginsburg, PM, Hornbuckle, K, Kefalas, C, Koch, T, Lehrer, J, Lembo, A, O'Brien, J, Papp, J, Parkman, H, Perumalsamy, KS, Iyer, PG, Roach, A, Sampliner, R, Sonnenberg, A, Vargo, J, Vege, SS, Vela, M, Zein, N & Zuckerman, MJ 2009, 'Guidelines for prevention of NSAID-related ulcer complications', American Journal of Gastroenterology, vol. 104, no. 3, pp. 728-738. https://doi.org/10.1038/ajg.2009.115
Lanza FL, Chan FKL, Quigley EMM, Inadomi J, Baroni D, Bernstein D et al. Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology. 2009 Mar;104(3):728-738. https://doi.org/10.1038/ajg.2009.115
Lanza, Frank L. ; Chan, Francis K L ; Quigley, Eamonn M M ; Inadomi, John ; Baroni, Darren ; Bernstein, David ; Brugge, William ; Chang, Lin ; Cunningham, John ; Dendrinos, Kleanthis G. ; DeVault, Kenneth ; Edmundowicz, Steven ; Ginsburg, Philip M. ; Hornbuckle, Kelvin ; Kefalas, Costas ; Koch, Timothy ; Lehrer, Jenifer ; Lembo, Anthony ; O'Brien, John ; Papp, John ; Parkman, Henry ; Perumalsamy, Kumaravel S. ; Iyer, Prasad G ; Roach, Albert ; Sampliner, Richard ; Sonnenberg, Amnon ; Vargo, John ; Vege, Santhi Swaroop ; Vela, Marcelo ; Zein, Nizar ; Zuckerman, Marc J. / Guidelines for prevention of NSAID-related ulcer complications. In: American Journal of Gastroenterology. 2009 ; Vol. 104, No. 3. pp. 728-738.
@article{4d9affc57d3c4e4c80463f69bb6ce01e,
title = "Guidelines for prevention of NSAID-related ulcer complications",
abstract = "Guidelines for clinical practice are intended to indicate preferred approaches to medical problems as established by scientifically valid research. Double-blind, placebo-controlled studies are preferable, but compassionate use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. Only when data that will not withstand objective scrutiny are available is a recommendation identified as a consensus of experts. Guidelines are applicable to all physicians who address the subject, without regard to specialty training or interests, and are intended to indicate the preferable, but not necessarily the only, acceptable approach to a specific problem. Guidelines are intended to be flexible and must be distinguished from standards of care, which are inflexible and rarely violated. Given the wide range of specifics in any health-care problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. These guidelines were developed under the auspices of the American College of Gastroenterology by a committee of experts in the field, reviewed by its Practice Parameters Committee, and approved by the Board of Trustees. The recommendations of these guidelines are therefore considered valid at the time of production based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at an established time and indicated at publication to assure continued validity. Owing to the volume of new data on the subject of non-steroidal anti-inflammatory drug (NSAID)-related injury to the upper gastrointestinal tract, i.e., the advent of cyclooxygenase (COX)-2 inhibitors, new data on interactions between these agents, as well as traditional NSAIDs, with aspirin and H. pylori, it was elected by the Committee to confine these guidelines to upper gastrointestinal (GI) injury and to leave post-duodenal injury as the subject of a separate guideline.",
author = "Lanza, {Frank L.} and Chan, {Francis K L} and Quigley, {Eamonn M M} and John Inadomi and Darren Baroni and David Bernstein and William Brugge and Lin Chang and John Cunningham and Dendrinos, {Kleanthis G.} and Kenneth DeVault and Steven Edmundowicz and Ginsburg, {Philip M.} and Kelvin Hornbuckle and Costas Kefalas and Timothy Koch and Jenifer Lehrer and Anthony Lembo and John O'Brien and John Papp and Henry Parkman and Perumalsamy, {Kumaravel S.} and Iyer, {Prasad G} and Albert Roach and Richard Sampliner and Amnon Sonnenberg and John Vargo and Vege, {Santhi Swaroop} and Marcelo Vela and Nizar Zein and Zuckerman, {Marc J.}",
year = "2009",
month = "3",
doi = "10.1038/ajg.2009.115",
language = "English (US)",
volume = "104",
pages = "728--738",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Guidelines for prevention of NSAID-related ulcer complications

AU - Lanza, Frank L.

AU - Chan, Francis K L

AU - Quigley, Eamonn M M

AU - Inadomi, John

AU - Baroni, Darren

AU - Bernstein, David

AU - Brugge, William

AU - Chang, Lin

AU - Cunningham, John

AU - Dendrinos, Kleanthis G.

AU - DeVault, Kenneth

AU - Edmundowicz, Steven

AU - Ginsburg, Philip M.

AU - Hornbuckle, Kelvin

AU - Kefalas, Costas

AU - Koch, Timothy

AU - Lehrer, Jenifer

AU - Lembo, Anthony

AU - O'Brien, John

AU - Papp, John

AU - Parkman, Henry

AU - Perumalsamy, Kumaravel S.

AU - Iyer, Prasad G

AU - Roach, Albert

AU - Sampliner, Richard

AU - Sonnenberg, Amnon

AU - Vargo, John

AU - Vege, Santhi Swaroop

AU - Vela, Marcelo

AU - Zein, Nizar

AU - Zuckerman, Marc J.

PY - 2009/3

Y1 - 2009/3

N2 - Guidelines for clinical practice are intended to indicate preferred approaches to medical problems as established by scientifically valid research. Double-blind, placebo-controlled studies are preferable, but compassionate use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. Only when data that will not withstand objective scrutiny are available is a recommendation identified as a consensus of experts. Guidelines are applicable to all physicians who address the subject, without regard to specialty training or interests, and are intended to indicate the preferable, but not necessarily the only, acceptable approach to a specific problem. Guidelines are intended to be flexible and must be distinguished from standards of care, which are inflexible and rarely violated. Given the wide range of specifics in any health-care problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. These guidelines were developed under the auspices of the American College of Gastroenterology by a committee of experts in the field, reviewed by its Practice Parameters Committee, and approved by the Board of Trustees. The recommendations of these guidelines are therefore considered valid at the time of production based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at an established time and indicated at publication to assure continued validity. Owing to the volume of new data on the subject of non-steroidal anti-inflammatory drug (NSAID)-related injury to the upper gastrointestinal tract, i.e., the advent of cyclooxygenase (COX)-2 inhibitors, new data on interactions between these agents, as well as traditional NSAIDs, with aspirin and H. pylori, it was elected by the Committee to confine these guidelines to upper gastrointestinal (GI) injury and to leave post-duodenal injury as the subject of a separate guideline.

AB - Guidelines for clinical practice are intended to indicate preferred approaches to medical problems as established by scientifically valid research. Double-blind, placebo-controlled studies are preferable, but compassionate use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. Only when data that will not withstand objective scrutiny are available is a recommendation identified as a consensus of experts. Guidelines are applicable to all physicians who address the subject, without regard to specialty training or interests, and are intended to indicate the preferable, but not necessarily the only, acceptable approach to a specific problem. Guidelines are intended to be flexible and must be distinguished from standards of care, which are inflexible and rarely violated. Given the wide range of specifics in any health-care problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. These guidelines were developed under the auspices of the American College of Gastroenterology by a committee of experts in the field, reviewed by its Practice Parameters Committee, and approved by the Board of Trustees. The recommendations of these guidelines are therefore considered valid at the time of production based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at an established time and indicated at publication to assure continued validity. Owing to the volume of new data on the subject of non-steroidal anti-inflammatory drug (NSAID)-related injury to the upper gastrointestinal tract, i.e., the advent of cyclooxygenase (COX)-2 inhibitors, new data on interactions between these agents, as well as traditional NSAIDs, with aspirin and H. pylori, it was elected by the Committee to confine these guidelines to upper gastrointestinal (GI) injury and to leave post-duodenal injury as the subject of a separate guideline.

UR - http://www.scopus.com/inward/record.url?scp=61949239030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61949239030&partnerID=8YFLogxK

U2 - 10.1038/ajg.2009.115

DO - 10.1038/ajg.2009.115

M3 - Article

C2 - 19240698

AN - SCOPUS:61949239030

VL - 104

SP - 728

EP - 738

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 3

ER -