Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults

S. Silberstein; P. Tfelt-Hansen; D. W. Dodick; V. Limmroth; R. B. Lipton; J. Pascual; S. J. Wang

doi:10.1111/j.1468-2982.2008.01555.x

Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults

S. Silberstein, P. Tfelt-Hansen, D. W. Dodick, V. Limmroth, R. B. Lipton, J. Pascual, S. J. Wang

Neurology

Research output: Contribution to journal › Review article › peer-review

215 Scopus citations

Abstract

In 1991 the Clinical Trials Subcommittee of the International Headache Society (IHS) developed and published its first edition of the Guidelines on controlled trials of drugs in episodic migraine because only quality trials can form the basis for international collaboration on drug therapy, and these Guidelines would 'improve the quality of controlled clinical trials in migraine'. With the current trend for large multinational trials, there is a need for increased awareness of methodological issues in clinical trials of drugs and other treatments for chronic migraine. These Guidelines are intended to assist in the design of well-controlled clinical trials of chronic migraine in adults, and do not apply to studies in children or adolescents.

Original language	English (US)
Pages (from-to)	484-495
Number of pages	12
Journal	Cephalalgia
Volume	28
Issue number	5
DOIs	https://doi.org/10.1111/j.1468-2982.2008.01555.x
State	Published - May 2008

Keywords

Chronic migraine
Clinical trials
Headache
Medication-overuse headache
Prophylactic treatment

ASJC Scopus subject areas

Clinical Neurology

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10.1111/j.1468-2982.2008.01555.x

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abstract = "In 1991 the Clinical Trials Subcommittee of the International Headache Society (IHS) developed and published its first edition of the Guidelines on controlled trials of drugs in episodic migraine because only quality trials can form the basis for international collaboration on drug therapy, and these Guidelines would 'improve the quality of controlled clinical trials in migraine'. With the current trend for large multinational trials, there is a need for increased awareness of methodological issues in clinical trials of drugs and other treatments for chronic migraine. These Guidelines are intended to assist in the design of well-controlled clinical trials of chronic migraine in adults, and do not apply to studies in children or adolescents.",

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AU - Tfelt-Hansen, P.

AU - Dodick, D. W.

AU - Limmroth, V.

AU - Lipton, R. B.

AU - Pascual, J.

AU - Wang, S. J.

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AB - In 1991 the Clinical Trials Subcommittee of the International Headache Society (IHS) developed and published its first edition of the Guidelines on controlled trials of drugs in episodic migraine because only quality trials can form the basis for international collaboration on drug therapy, and these Guidelines would 'improve the quality of controlled clinical trials in migraine'. With the current trend for large multinational trials, there is a need for increased awareness of methodological issues in clinical trials of drugs and other treatments for chronic migraine. These Guidelines are intended to assist in the design of well-controlled clinical trials of chronic migraine in adults, and do not apply to studies in children or adolescents.

KW - Chronic migraine

KW - Clinical trials

KW - Headache

KW - Medication-overuse headache

KW - Prophylactic treatment

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Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults

Abstract

Keywords

ASJC Scopus subject areas

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