Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

Ivor D. Hill, Martha H. Dirks, Gregory S. Liptak, Richard B. Colletti, Alessio Fasano, Stefano Guandalini, Edward J. Hoffenberg, Karoly Horvath, Joseph A Murray, Mitchell Pivor, Ernest G. Seidman

Research output: Contribution to journalReview article

844 Citations (Scopus)

Abstract

Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs in children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty and persistent iron deficiency anemia and in asymptomatic individuals with type 1 diabetes, Down syndrome, Turner syndrome, Williams syndrome, selective immunoglobulin (Ig)A deficiency and first degree relatives of individuals with celiac disease. The Celiac Disease Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition has formulated a clinical practice guideline for the diagnosis and treatment of pediatric celiac disease based on an integration of a systematic review of the medical literature combined with expert opinion. The Committee examined the indications for testing, the value of serological tests, human leukocyte antigen (HLA) typing and histopathology and the treatment and monitoring of children with celiac disease. It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for celiac disease have a blood test for antibody to tissue transglutaminase (TTG), that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and that those with the characteristics of celiac disease on intestinal histopathology be treated with a strict gluten-free diet. This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume40
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

celiac disease
Celiac Disease
Guidelines
Therapeutics
protein-glutamine gamma-glutamyltransferase
committees
histopathology
Delayed Puberty
Pediatrics
Williams Syndrome
Dermatitis Herpetiformis
gluten-free diet
tooth enamel
Down syndrome
Gluten-Free Diet
immunoglobulin A
iron deficiency anemia
Turner Syndrome
Iron-Deficiency Anemias
hematologic tests

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Guideline for the diagnosis and treatment of celiac disease in children : Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. / Hill, Ivor D.; Dirks, Martha H.; Liptak, Gregory S.; Colletti, Richard B.; Fasano, Alessio; Guandalini, Stefano; Hoffenberg, Edward J.; Horvath, Karoly; Murray, Joseph A; Pivor, Mitchell; Seidman, Ernest G.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 40, No. 1, 01.2005, p. 1-19.

Research output: Contribution to journalReview article

Hill, Ivor D. ; Dirks, Martha H. ; Liptak, Gregory S. ; Colletti, Richard B. ; Fasano, Alessio ; Guandalini, Stefano ; Hoffenberg, Edward J. ; Horvath, Karoly ; Murray, Joseph A ; Pivor, Mitchell ; Seidman, Ernest G. / Guideline for the diagnosis and treatment of celiac disease in children : Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. In: Journal of Pediatric Gastroenterology and Nutrition. 2005 ; Vol. 40, No. 1. pp. 1-19.
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