Guidance on short-term management of atrial fibrillation in coronavirus disease 2019

Pattara Rattanawong, Win-Kuang Shen, Hicham El Masry, Dan Sorajja, Komandoor Srivathsan, Arturo Valverde, Luis R. Scott

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Atrial fibrillation is a common clinical manifestation in hospitalized patients with coronavirus disease 2019 (COVID-19). Medications used to treat atrial fibrillation, such as antiarrhythmic drugs and anticoagulants, may have significant drug interactions with emerging COVID-19 treatments. Common unintended nontherapeutic target effects of COVID-19 treatment include potassium channel blockade, cytochrome P 450 isoenzyme inhibition or activation, and P-glycoprotein inhibition. Drug-drug interactions with antiarrhythmic drugs and anticoagulants in these patients may lead to significant bradycardia, ventricular arrhythmias, or severe bleeding. It is important for clinicians to be aware of these interactions, drug metabolism changes, and clinical consequences when choosing antiarrhythmic drugs and anticoagulants for COVID-19 patients with atrial fibrillation. The objective of this review is to provide a practical guide for clinicians who are managing COVID-19 patients with concomitant atrial fibrillation.

Original languageEnglish (US)
Article numbere017529
JournalJournal of the American Heart Association
Volume9
Issue number14
DOIs
StatePublished - Jul 21 2020

Keywords

  • Antiarrhythmic drug
  • Atrial fibrillation
  • COVID-19

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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