Guanylate cyclase C signaling: An intestinal secretory pathway where bugs, genes and new drugs intersect

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

Acute infectious and chronic diarrheal diseases are important public health problems. A recent study by Fiskerstrand and colleagues identified a family with a rare early onset familial diarrhea. By linkage analysis and exon sequencing, the authors identified a heterozygous missense mutation in GUCY2C, encoding the guanylate cyclase C receptor, which is involved in intestinal secretion. This newly identified gene in the etiology of a familial diarrhea provides a candidate target for the development not only of new treatments for diarrhea, but also of a new drug class to treat constipation.

Original languageEnglish (US)
Article number50
JournalGenome medicine
Volume4
Issue number6
DOIs
StatePublished - Jun 26 2012

Keywords

  • Agonist
  • Diarrhea
  • Familial
  • GUCY2C
  • Genetic
  • Guanylate cyclase C
  • Secretion

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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