Guanethidine sympathectomy increases substance P concentration in the superior sympathetic ganglion of adult rats

Eduardo E. Benarroch, Paula J. Zollman, James D. Schmelzer, Daniel K. Nelson, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Adult rats received intraperitoneal injections of guanethidine or saline for 5 weeks. Six to 8 weeks following completion of treatment, concentrations of substance P and neuropeptide Y (NPY) were measured by radioimmunoassay in the superior cervical ganglion (SCG) and thoracic spinal cord. The SCG was also immunostained for NPY and substance P. No differences were observed in thoracic spinal cord content of either NPY or substance P. We observed depletion of NPY immunoreactive neurons and NPY levels in the SCG, and pharmacologic evidence of postganglionic denervation in guanethidine-treated rats. In guanethidine-treated rats, there was a marked increase of substance P levels in the SCG, where substance P was localized in fibers, but not cell bodies. Thus, sprouting of substance P-containing sensory fibers in the sympathetic ganglia occurs following postganglionic sympathectomy in adult rats.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalBrain Research
Volume584
Issue number1-2
DOIs
StatePublished - Jul 3 1992

Keywords

  • Guanethidine
  • Neuropeptide Y
  • Substance P
  • Superior cervical ganglion
  • Sympathectomy
  • Thoracic cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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