Guanethidine adrenergic neuropathy: an animal model of selective autonomic neuropathy

Douglas W. Zochodne, Kim K. Ward, Phillip Anson Low

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chronic administration of guanethidine to adult rats induces a selective autoimmune adrenergic neuropathy. Physiological and biochemical features of this disorder in the peripheral nervous system were explored in young adult Sprague-Dawley rats given daily intraperitoneal guanethidine monosulfate for 5 weeks. Control rats received daily saline injections. The guanethidine-treated animals gained less weight, had ptosis, and had a lower mean arterial blood pressure in the supine and upright tilted positions. Norepinephrine was depleted in the peroneal, sural, tibial, and vagal nerves, the nutrient artery to the tibial nerve and in the superior cervical sympathetic ganglion of the drug-treated animals. On light microscopy, there was an inflammatory cell infiltrate and neuron loss in the superior cervical ganglion. Caudal and sciatic-tibial nerve conduction values were well preserved in the guanethidine-treated animals as was the 'C' potential derived from unmyelinated vagal fibers recorded in an in vitro chamber. The 'C' potential recorded from the cervical sympathetic trunk, however, was reduced in amplitude correlating with the loss of norepinephrine content in the harvested contralateral superior cervical sympathetic ganglion. The findings further support the view that guanethidine produces a selective adrenergic neuropathy in the rat - providing a useful standard with which to gauge autonomic involvement in other models of neuropathy. In addition, loss of the cervical sympathetic 'C' potential suggests that this presumed preganglionic structure also contains postganglionic adrenergic fibers.

Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalBrain Research
Volume461
Issue number1
DOIs
StatePublished - Sep 27 1988

Fingerprint

Guanethidine
Adrenergic Agents
Animal Models
Superior Cervical Ganglion
Tibial Nerve
Sympathetic Ganglia
Norepinephrine
Arterial Pressure
Adrenergic Fibers
Neural Conduction
Peripheral Nervous System Diseases
Sciatic Nerve
Sprague Dawley Rats
Young Adult
Microscopy
Arteries
Neurons
Light
Weights and Measures
Food

Keywords

  • Adrenergic neuropathy
  • Autonomic neuropathy
  • Guanethidine sulfate

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Guanethidine adrenergic neuropathy : an animal model of selective autonomic neuropathy. / Zochodne, Douglas W.; Ward, Kim K.; Low, Phillip Anson.

In: Brain Research, Vol. 461, No. 1, 27.09.1988, p. 10-16.

Research output: Contribution to journalArticle

Zochodne, Douglas W. ; Ward, Kim K. ; Low, Phillip Anson. / Guanethidine adrenergic neuropathy : an animal model of selective autonomic neuropathy. In: Brain Research. 1988 ; Vol. 461, No. 1. pp. 10-16.
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