Guamanian neurodegenerative disease: Ultrastructural studies of skin

Seiitsu Ono, Stephen C. Waring, Leonard L. Kurland, Ulla Katrina-Craig, Ronald Carl Petersen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It is evident that Guamanian amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) are clinical variants of a single disease entity and that Guamanian ALS is clinically indistinguishable from sporadic ALS. We studied by electron microscopy the skin tissues from 11 patients with Guamanian neurodegenerative disease (PDC and ALS), 11 Chamorro control subjects, 10 Japanese patients with sporadic ALS and 11 Japanese control patients. Among patients with sporadic ALS, there was an inverse relationship of collagen fiber diameter and the duration of disease and a marked increase of amorphous material in the ground substance. These findings were not observed in the Guamanian patients or controls. Therefore, the skin studies reinforce the view of a different disease mechanism in Guamanian ALS and PDC compared to sporadic ALS.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalJournal of the Neurological Sciences
Volume146
Issue number1
DOIs
StatePublished - Feb 27 1997

Fingerprint

Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis
Parkinsonian Disorders
Skin
Dementia
Electron Microscopy
Collagen
Amyotrophic lateral sclerosis 1
Amyotrophic Lateral Sclerosis 11

Keywords

  • amyotrophic lateral sclerosis
  • collagen
  • Parkinsonism-dementia complex
  • skin

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Guamanian neurodegenerative disease : Ultrastructural studies of skin. / Ono, Seiitsu; Waring, Stephen C.; Kurland, Leonard L.; Katrina-Craig, Ulla; Petersen, Ronald Carl.

In: Journal of the Neurological Sciences, Vol. 146, No. 1, 27.02.1997, p. 35-40.

Research output: Contribution to journalArticle

Ono, Seiitsu ; Waring, Stephen C. ; Kurland, Leonard L. ; Katrina-Craig, Ulla ; Petersen, Ronald Carl. / Guamanian neurodegenerative disease : Ultrastructural studies of skin. In: Journal of the Neurological Sciences. 1997 ; Vol. 146, No. 1. pp. 35-40.
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