Gq signaling is required for allergen-induced pulmonary eosinophilia

Michael T. Borchers, Paul J. Justice, Tracy Ansay, Valeria Mancino, Michael P. McGarry, Jeffrey Crosby, Melvin I. Simon, Nancy A. Lee, James J. Lee

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The complexity and magnitude of interactions leading to the selective infiltration of eosinophils in response to inhaled allergens are formidable obstacles to a larger understanding of the pulmonary pathology associated with allergic asthma. This study uses knockout mice to demonstrate a novel function for the heterotrimeric G protein, Gq, in the regulation of pulmonary eosinophil recruitment. In the absence of Gq signaling, eosinophils failed to accumulate in the lungs following allergen challenge. These studies demonstrate that the inhibition of eosinophil accumulation in the airways is attributed to the failure of hemopoietically derived cells to elaborate GM-CSF in the airways. The data suggest that activation of a Gq-coupled receptor(s) on resident leukocytes in the lung elicits expression of GM-CSF, which, in turn, is required for allergen-induced pulmonary eosinophilia, identifying a novel pathway of eosinophil-associated effector functions leading to pulmonary pathology in diseases such as asthma.

Original languageEnglish (US)
Pages (from-to)3543-3549
Number of pages7
JournalJournal of Immunology
Volume168
Issue number7
DOIs
StatePublished - Apr 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Borchers, M. T., Justice, P. J., Ansay, T., Mancino, V., McGarry, M. P., Crosby, J., Simon, M. I., Lee, N. A., & Lee, J. J. (2002). Gq signaling is required for allergen-induced pulmonary eosinophilia. Journal of Immunology, 168(7), 3543-3549. https://doi.org/10.4049/jimmunol.168.7.3543