Growth self-incitement in murine melanoma B16: A phenomenological model

Žeuko Bajzer, Krešimir Pavellé, Stanimir Vuk-pavlović

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The growing marine melanoma B16 secretes increasing quantities of a substance or substances immunologically cross-reactive with insulin. The elevated concentrations of these substances in blood are accompanied by a decrease in blood glucose concentration and release of growth hormone, which is followed by increased tumor growth. By use of a phenomenological model based on these data, we show that B16 incites its own growth by positive feedback.

Original languageEnglish (US)
Pages (from-to)930-932
Number of pages3
JournalScience
Volume225
Issue number4665
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • General

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