TY - JOUR
T1 - Growth self-incitement in murine melanoma B16
T2 - A phenomenological model
AU - Bajzer, Žeuko
AU - Pavellé, Krešimir
AU - Vuk-pavlović, Stanimir
PY - 1984
Y1 - 1984
N2 - The growing marine melanoma B16 secretes increasing quantities of a substance or substances immunologically cross-reactive with insulin. The elevated concentrations of these substances in blood are accompanied by a decrease in blood glucose concentration and release of growth hormone, which is followed by increased tumor growth. By use of a phenomenological model based on these data, we show that B16 incites its own growth by positive feedback.
AB - The growing marine melanoma B16 secretes increasing quantities of a substance or substances immunologically cross-reactive with insulin. The elevated concentrations of these substances in blood are accompanied by a decrease in blood glucose concentration and release of growth hormone, which is followed by increased tumor growth. By use of a phenomenological model based on these data, we show that B16 incites its own growth by positive feedback.
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U2 - 10.1126/science.6382606
DO - 10.1126/science.6382606
M3 - Article
C2 - 6382606
AN - SCOPUS:0021275728
SN - 0036-8075
VL - 225
SP - 930
EP - 932
JO - Science
JF - Science
IS - 4665
ER -