Growth of SJL/J-derived RCS as related to its ability to induce T cell proliferation in the host. II. Negative influence of H-2(dl)

I. R. Katz, J. Chapman-Alexander, S. P. Lerman, C. S. David, G. J. Thorbecke

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Abstract

Backcross SJL x (SJL x BALB/c)F1 and (SJL x BSVS)F1 mice were examined for their ability to support growth of transplantable SJL lymphoma (reticulum cell sarcoma (RCS)). A marked linkage to H-2 was noted in that H-2(s/d) backcross mice failed to support tumor growth, while H-2(s/s) backcross mice showed approximately 70% of the growth seen in SJL mice, as judged by lymph node and spleen weights. Spleen cells obtained from backcross ability to give proliferative responses to γ-RCS cells, whereafter individual splenectomized mice were also examined for their ability to support lymphoma growth. Both properties showed a similar degree of linkage to H-2 and to each other, although there seemed to be a segregating non-H-2 BALB gene which also exerted an additional, less marked negative influence on the proliferative response in vivo may contribute to the lymphoma growth and that the presence of H-2(d) is inhibitory. (SJL x BSVS)F1 mice gave excellent proliferative responses and supported growth of RCS to approximately 80% of those of controls. These results confirm previous conclusions on the negative effect of H-21(d) in F1 hybrids on both phenomena.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalTransplantation
Volume33
Issue number2
StatePublished - 1982

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Non-Hodgkin's Lymphoma
Cell Proliferation
T-Lymphocytes
Growth
Lymphoma
Spleen
Lymph Nodes
Weights and Measures
Genes
Neoplasms

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Katz, I. R., Chapman-Alexander, J., Lerman, S. P., David, C. S., & Thorbecke, G. J. (1982). Growth of SJL/J-derived RCS as related to its ability to induce T cell proliferation in the host. II. Negative influence of H-2(dl). Transplantation, 33(2), 134-137.

Growth of SJL/J-derived RCS as related to its ability to induce T cell proliferation in the host. II. Negative influence of H-2(dl). / Katz, I. R.; Chapman-Alexander, J.; Lerman, S. P.; David, C. S.; Thorbecke, G. J.

In: Transplantation, Vol. 33, No. 2, 1982, p. 134-137.

Research output: Contribution to journalArticle

Katz, IR, Chapman-Alexander, J, Lerman, SP, David, CS & Thorbecke, GJ 1982, 'Growth of SJL/J-derived RCS as related to its ability to induce T cell proliferation in the host. II. Negative influence of H-2(dl)', Transplantation, vol. 33, no. 2, pp. 134-137.
Katz, I. R. ; Chapman-Alexander, J. ; Lerman, S. P. ; David, C. S. ; Thorbecke, G. J. / Growth of SJL/J-derived RCS as related to its ability to induce T cell proliferation in the host. II. Negative influence of H-2(dl). In: Transplantation. 1982 ; Vol. 33, No. 2. pp. 134-137.
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