Backcross SJL x (SJL x BALB/c)F1 and (SJL x BSVS)F1 mice were examined for their ability to support growth of transplantable SJL lymphoma (reticulum cell sarcoma (RCS)). A marked linkage to H-2 was noted in that H-2(s/d) backcross mice failed to support tumor growth, while H-2(s/s) backcross mice showed approximately 70% of the growth seen in SJL mice, as judged by lymph node and spleen weights. Spleen cells obtained from backcross ability to give proliferative responses to γ-RCS cells, whereafter individual splenectomized mice were also examined for their ability to support lymphoma growth. Both properties showed a similar degree of linkage to H-2 and to each other, although there seemed to be a segregating non-H-2 BALB gene which also exerted an additional, less marked negative influence on the proliferative response in vivo may contribute to the lymphoma growth and that the presence of H-2(d) is inhibitory. (SJL x BSVS)F1 mice gave excellent proliferative responses and supported growth of RCS to approximately 80% of those of controls. These results confirm previous conclusions on the negative effect of H-21(d) in F1 hybrids on both phenomena.
|Original language||English (US)|
|Number of pages||4|
|State||Published - 1982|
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