Growth modeling of the maternal cytokine milieu throughout normal pregnancy: Macrophage-derived chemokine decreases as inflammation/counterregulation increases

Shernan G. Holtan, Yiyi Chen, Rajani Kaimal, Douglas J. Creedon, Elizabeth Ann L Enninga, Wendy K. Nevala, Svetomir Nenad Markovic

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women N=16 at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.

Original languageEnglish (US)
Article number952571
JournalJournal of Immunology Research
Volume2015
DOIs
StatePublished - 2015

Fingerprint

Chemokine CCL22
Mothers
Cytokines
Inflammation
Pregnancy
Growth
Interleukin-9
Interleukin-12 Subunit p40
Interleukin 1 Receptor Antagonist Protein
Interleukin-15
CD40 Ligand
Interleukin-13
Interleukin-3
First Pregnancy Trimester
Interleukin-8
Interleukin-1
Pregnant Women
Interleukin-6
Parturition
Ligands

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Growth modeling of the maternal cytokine milieu throughout normal pregnancy : Macrophage-derived chemokine decreases as inflammation/counterregulation increases. / Holtan, Shernan G.; Chen, Yiyi; Kaimal, Rajani; Creedon, Douglas J.; Enninga, Elizabeth Ann L; Nevala, Wendy K.; Markovic, Svetomir Nenad.

In: Journal of Immunology Research, Vol. 2015, 952571, 2015.

Research output: Contribution to journalArticle

Holtan, Shernan G. ; Chen, Yiyi ; Kaimal, Rajani ; Creedon, Douglas J. ; Enninga, Elizabeth Ann L ; Nevala, Wendy K. ; Markovic, Svetomir Nenad. / Growth modeling of the maternal cytokine milieu throughout normal pregnancy : Macrophage-derived chemokine decreases as inflammation/counterregulation increases. In: Journal of Immunology Research. 2015 ; Vol. 2015.
@article{d64a3e7f5d78488db799dedeedec2f9c,
title = "Growth modeling of the maternal cytokine milieu throughout normal pregnancy: Macrophage-derived chemokine decreases as inflammation/counterregulation increases",
abstract = "Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women N=16 at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.",
author = "Holtan, {Shernan G.} and Yiyi Chen and Rajani Kaimal and Creedon, {Douglas J.} and Enninga, {Elizabeth Ann L} and Nevala, {Wendy K.} and Markovic, {Svetomir Nenad}",
year = "2015",
doi = "10.1155/2015/952571",
language = "English (US)",
volume = "2015",
journal = "Journal of Immunology Research",
issn = "2314-8861",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Growth modeling of the maternal cytokine milieu throughout normal pregnancy

T2 - Macrophage-derived chemokine decreases as inflammation/counterregulation increases

AU - Holtan, Shernan G.

AU - Chen, Yiyi

AU - Kaimal, Rajani

AU - Creedon, Douglas J.

AU - Enninga, Elizabeth Ann L

AU - Nevala, Wendy K.

AU - Markovic, Svetomir Nenad

PY - 2015

Y1 - 2015

N2 - Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women N=16 at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.

AB - Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women N=16 at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.

UR - http://www.scopus.com/inward/record.url?scp=84926482968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926482968&partnerID=8YFLogxK

U2 - 10.1155/2015/952571

DO - 10.1155/2015/952571

M3 - Article

C2 - 25866828

AN - SCOPUS:84926482968

VL - 2015

JO - Journal of Immunology Research

JF - Journal of Immunology Research

SN - 2314-8861

M1 - 952571

ER -