Growth hormone enhances thymic function in HIV-1-infected adults

Laura A. Napolitano, Diane Schmidt, Michael B. Gotway, Niloufar Ameli, Erin L. Filbert, Myra M. Ng, Julie L. Clor, Lorrie Epling, Elizabeth Sinclair, Paul D. Baum, Kai Li, Marisela Lua Killian, Peter Bacchetti, Joseph M. McCune

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Growth hormone (GH) is an underappreciated but important regulator of T cell development that can reverse age-related declines in thymopoiesis in rodents. Here, we report findings of a prospective randomized study examining the effects of GH on the immune system of HIV-1-infected adults. GH treatment was associated with increased thymic mass. In addition, GH treatment enhanced thymic output, as measured by both the frequency of T cell receptor rearrangement excision circles in circulating T cells and the numbers of circulating naive and total CD4+ T cells. These findings provide compelling evidence that GH induces de novo T cell production and may, accordingly, facilitate CD4+ T cell recovery in HIV-1-infected adults. Further, these randomized, prospective data have shown that thymic involution can be pharmacologically reversed in humans, suggesting that immune-based therapies could be used to enhance thymopoiesis in immunodeficient individuals.

Original languageEnglish (US)
Pages (from-to)1085-1098
Number of pages14
JournalJournal of Clinical Investigation
Volume118
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Medicine(all)

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    Napolitano, L. A., Schmidt, D., Gotway, M. B., Ameli, N., Filbert, E. L., Ng, M. M., Clor, J. L., Epling, L., Sinclair, E., Baum, P. D., Li, K., Killian, M. L., Bacchetti, P., & McCune, J. M. (2008). Growth hormone enhances thymic function in HIV-1-infected adults. Journal of Clinical Investigation, 118(3), 1085-1098. https://doi.org/10.1172/JCI32830