Growth hormone and lipids

U. Keller, J. M. Miles

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

It has been known for more than 30 years that growth hormone has a lipolytic properties and growth hormone excess (acromegaly) and growth hormone deficiency have been reported to be associated with abnormalities in serum lipoprotein concentrations. Due to the lipolytic effect of growth hormone, its administration in man has been reported to increase plasma nonesterified fatty acid (NEFA) concentrations. Ketone body production increases during acute growth hormone excess as a result of increased NEFA concentrations; similarly, the increase in serum triglycerides may be explained by an increase in substrate (NEFA) supply to the liver for VLDL production. The effect may be enhanced by a simultaneous decrease of serum lipoprotein lipase activity. The cholesterol-lowering effect of growth hormone administration has not been investigated in detail, specifically, the effect of growth hormone on LDL kinetics is unknown. Growth hormone-excess and growth hormone deficiency have been reported to be associated with increased risk for atherosclerosis; an association with serum lipoprotein changes is likely but evidence for a causal link is yet lacking.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalHormone Research
Volume36
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1991

Keywords

  • Acromegaly
  • Free fatty acids
  • Growth hormone
  • Insulin
  • Insulin-like growth factor-1
  • Ketone bodies
  • Ketone body kinetics
  • LDL-cholesterol
  • Lipolysis
  • Lipoproteins
  • Pituitary
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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  • Cite this

    Keller, U., & Miles, J. M. (1991). Growth hormone and lipids. Hormone Research, 36(SUPPL. 1), 36-40. https://doi.org/10.1159/000182186