TY - JOUR
T1 - Growth factor treatment of demyelinating disease
T2 - At last, a leap into the light
AU - Ransohoff, Richard M.
AU - Howe, Charles L.
AU - Rodriguez, Moses
N1 - Funding Information:
Research in Dr Ransohoff's laboratory is supported by the National Institutes of Health (1PO1 NS38667; 3RO1 NS32151). We apologize to those investigators whose work in this field could not be cited owing to space limitations.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Researchers seeking treatments for multiple sclerosis (MS) have long dreamed of using neurotrophic factors to enhance remyelination. Previous attempts to apply trophic support for oligodendrocytes in experimental demyelination uniformly produced complicated outcomes that reflected unexpected effects on immune or inflammatory responses and could be interpreted only with caution. Now, two recent publications have demonstrated convincingly that cytokines of the interleukin (IL)-6 superfamily can ameliorate experimental autoimmune encephalomyelitis and promote oligodendrocyte survival, without demonstrable effect on inflammation or immune responses.
AB - Researchers seeking treatments for multiple sclerosis (MS) have long dreamed of using neurotrophic factors to enhance remyelination. Previous attempts to apply trophic support for oligodendrocytes in experimental demyelination uniformly produced complicated outcomes that reflected unexpected effects on immune or inflammatory responses and could be interpreted only with caution. Now, two recent publications have demonstrated convincingly that cytokines of the interleukin (IL)-6 superfamily can ameliorate experimental autoimmune encephalomyelitis and promote oligodendrocyte survival, without demonstrable effect on inflammation or immune responses.
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U2 - 10.1016/S1471-4906(02)02321-9
DO - 10.1016/S1471-4906(02)02321-9
M3 - Review article
C2 - 12401395
AN - SCOPUS:0036838576
SN - 1471-4906
VL - 23
SP - 512
EP - 516
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -