Growth factor mediated signaling in pancreatic pathogenesis

Debashis Nandy, Debabrata Mukhopadhyay

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed.

Original languageEnglish (US)
Pages (from-to)841-871
Number of pages31
JournalCancers
Volume3
Issue number1
DOIs
StatePublished - Mar 2011

Keywords

  • Growth factors
  • Pancreatic carcinoma
  • Pancreatitis
  • Signaling

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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