Group 5 drugs for multidrug-resistant tuberculosis: Individual patient data meta-analysis

Greg J. Fox; Andrea Benedetti; Helen Cox; Won Jung Koh; Piret Viiklepp; Shama Ahuja; Geoffrey Pasvol; Dick Menzies; S. Ahuja; D. Ashkin; M. Avendaño; R. Banerjee; M. Bauer; M. G. Hollm-Delgado; M. Pai; L. Shah; J. N. Bayona; M. Becerra; M. Burgos; R. Centis; L. D'Ambrosio; G. B. Migliori; E. D. Chan; C. Y. Chiang; W. C.M. De Lange; R. Van Altena; T. S. Van Der Werf; K. De Riemer; N. H. Dung; D. Enarson; D. Falzon; R. M. Granich; K. Flanagan; J. Flood; N. Gandhi; L. Garcia-Garcia; T. H. Holtz; M. Iseman; M. J. Strand; L. G. Jarlsberg; S. Royce; S. Keshavjee; H. R. Kim; C. D. Mitnick; J. Lancaster; M. Van Der Walt; C. Lange; V. Leimane; V. Riekstina; C. C. Leung; J. Li; M. Narita; P. O'Riordan; D. Palmero; S. K. Park; J. Pena; C. Pérez-Guzmán; A. Ponce-De-Leon; J. Sifuentes-Osornio; M. I.D. Quelapio; T. E. Tupasi; J. Robert; H. S. Schaaf; K. J. Seung; S. S. Shin; T. S. Shim; Y. Shiraishi; G. Sotgiu; P. Tabarsi; M. H. Vargas; J. Westenhouse; W. W. Yew; J. J. Yim

doi:10.1183/13993003.00993-2016

Group 5 drugs for multidrug-resistant tuberculosis: Individual patient data meta-analysis

Greg J. Fox, Andrea Benedetti, Helen Cox, Won Jung Koh, Piret Viiklepp, Shama Ahuja, Geoffrey Pasvol, Dick Menzies, S. Ahuja, D. Ashkin, M. Avendaño, R. Banerjee, M. Bauer, M. G. Hollm-Delgado, M. Pai, L. Shah, J. N. Bayona, M. Becerra, M. Burgos, R. CentisL. D'Ambrosio, G. B. Migliori, E. D. Chan, C. Y. Chiang, W. C.M. De Lange, R. Van Altena, T. S. Van Der Werf, K. De Riemer, N. H. Dung, D. Enarson, D. Falzon, R. M. Granich, K. Flanagan, J. Flood, N. Gandhi, L. Garcia-Garcia, T. H. Holtz, M. Iseman, M. J. Strand, L. G. Jarlsberg, S. Royce, S. Keshavjee, H. R. Kim, C. D. Mitnick, J. Lancaster, M. Van Der Walt, C. Lange, V. Leimane, V. Riekstina, C. C. Leung, J. Li, M. Narita, P. O'Riordan, D. Palmero, S. K. Park, J. Pena, C. Pérez-Guzmán, A. Ponce-De-Leon, J. Sifuentes-Osornio, M. I.D. Quelapio, T. E. Tupasi, J. Robert, H. S. Schaaf, K. J. Seung, S. S. Shin, T. S. Shim, Y. Shiraishi, G. Sotgiu, P. Tabarsi, M. H. Vargas, J. Westenhouse, W. W. Yew, J. J. Yim

Pediatric and Adolescent Medicine

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15 Scopus citations

Abstract

The role of so-called "group 5" second-line drugs as a part of antibiotic therapy for multidrug-resistant tuberculosis (MDR-TB) is widely debated. We performed an individual patient data meta-analysis to evaluate the effectiveness of several group 5 drugs including amoxicillin/clavulanic acid, thioacetazone, the macrolide antibiotics, linezolid, clofazimine and terizidone for treatment of patients with MDR-TB. Detailed individual patient data were obtained from 31 published cohort studies of MDR-TB therapy. Pooled treatment outcomes for each group 5 drug were calculated using a random effects meta-analysis. Primary analyses compared treatment success to a combined outcome of failure, relapse or death. Among 9282 included patients, 2191 received at least one group 5 drug. We found no improvement in treatment success among patients taking clofazimine, amoxicillin/clavulanic acid or macrolide antibiotics, despite applying a number of statistical approaches to control confounding. Thioacetazone was associated with increased treatment success (OR 2.6, 95% CI 1.1-6.1) when matched controls were selected from studies in which the group 5 drugs were not used at all, although this result was heavily influenced by a single study. The development of more effective antibiotics to treat drug-resistant TB remains an urgent priority.

Original language	English (US)
Article number	1600993
Journal	European Respiratory Journal
Volume	49
Issue number	1
DOIs	https://doi.org/10.1183/13993003.00993-2016
State	Published - Jan 1 2017

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/13993003.00993-2016

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Fox, G. J., Benedetti, A., Cox, H., Koh, W. J., Viiklepp, P., Ahuja, S., Pasvol, G., Menzies, D., Ahuja, S., Ashkin, D., Avendaño, M., Banerjee, R., Bauer, M., Hollm-Delgado, M. G., Pai, M., Shah, L., Bayona, J. N., Becerra, M., Burgos, M., ... Yim, J. J. (2017). Group 5 drugs for multidrug-resistant tuberculosis: Individual patient data meta-analysis. European Respiratory Journal, 49(1), Article 1600993. https://doi.org/10.1183/13993003.00993-2016

Fox, GJ, Benedetti, A, Cox, H, Koh, WJ, Viiklepp, P, Ahuja, S, Pasvol, G, Menzies, D, Ahuja, S, Ashkin, D, Avendaño, M, Banerjee, R, Bauer, M, Hollm-Delgado, MG, Pai, M, Shah, L, Bayona, JN, Becerra, M, Burgos, M, Centis, R, D'Ambrosio, L, Migliori, GB, Chan, ED, Chiang, CY, De Lange, WCM, Van Altena, R, Van Der Werf, TS, De Riemer, K, Dung, NH, Enarson, D, Falzon, D, Granich, RM, Flanagan, K, Flood, J, Gandhi, N, Garcia-Garcia, L, Holtz, TH, Iseman, M, Strand, MJ, Jarlsberg, LG, Royce, S, Keshavjee, S, Kim, HR, Mitnick, CD, Lancaster, J, Van Der Walt, M, Lange, C, Leimane, V, Riekstina, V, Leung, CC, Li, J, Narita, M, O'Riordan, P, Palmero, D, Park, SK, Pena, J, Pérez-Guzmán, C, Ponce-De-Leon, A, Sifuentes-Osornio, J, Quelapio, MID, Tupasi, TE, Robert, J, Schaaf, HS, Seung, KJ, Shin, SS, Shim, TS, Shiraishi, Y, Sotgiu, G, Tabarsi, P, Vargas, MH, Westenhouse, J, Yew, WW & Yim, JJ 2017, 'Group 5 drugs for multidrug-resistant tuberculosis: Individual patient data meta-analysis', European Respiratory Journal, vol. 49, no. 1, 1600993. https://doi.org/10.1183/13993003.00993-2016

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title = "Group 5 drugs for multidrug-resistant tuberculosis: Individual patient data meta-analysis",

abstract = "The role of so-called {"}group 5{"} second-line drugs as a part of antibiotic therapy for multidrug-resistant tuberculosis (MDR-TB) is widely debated. We performed an individual patient data meta-analysis to evaluate the effectiveness of several group 5 drugs including amoxicillin/clavulanic acid, thioacetazone, the macrolide antibiotics, linezolid, clofazimine and terizidone for treatment of patients with MDR-TB. Detailed individual patient data were obtained from 31 published cohort studies of MDR-TB therapy. Pooled treatment outcomes for each group 5 drug were calculated using a random effects meta-analysis. Primary analyses compared treatment success to a combined outcome of failure, relapse or death. Among 9282 included patients, 2191 received at least one group 5 drug. We found no improvement in treatment success among patients taking clofazimine, amoxicillin/clavulanic acid or macrolide antibiotics, despite applying a number of statistical approaches to control confounding. Thioacetazone was associated with increased treatment success (OR 2.6, 95% CI 1.1-6.1) when matched controls were selected from studies in which the group 5 drugs were not used at all, although this result was heavily influenced by a single study. The development of more effective antibiotics to treat drug-resistant TB remains an urgent priority.",

author = "Fox, {Greg J.} and Andrea Benedetti and Helen Cox and Koh, {Won Jung} and Piret Viiklepp and Shama Ahuja and Geoffrey Pasvol and Dick Menzies and S. Ahuja and D. Ashkin and M. Avenda{\~n}o and R. Banerjee and M. Bauer and Hollm-Delgado, {M. G.} and M. Pai and L. Shah and Bayona, {J. N.} and M. Becerra and M. Burgos and R. Centis and L. D'Ambrosio and Migliori, {G. B.} and Chan, {E. D.} and Chiang, {C. Y.} and {De Lange}, {W. C.M.} and {Van Altena}, R. and {Van Der Werf}, {T. S.} and {De Riemer}, K. and Dung, {N. H.} and D. Enarson and D. Falzon and Granich, {R. M.} and K. Flanagan and J. Flood and N. Gandhi and L. Garcia-Garcia and Holtz, {T. H.} and M. Iseman and Strand, {M. J.} and Jarlsberg, {L. G.} and S. Royce and S. Keshavjee and Kim, {H. R.} and Mitnick, {C. D.} and J. Lancaster and {Van Der Walt}, M. and C. Lange and V. Leimane and V. Riekstina and Leung, {C. C.} and J. Li and M. Narita and P. O'Riordan and D. Palmero and Park, {S. K.} and J. Pena and C. P{\'e}rez-Guzm{\'a}n and A. Ponce-De-Leon and J. Sifuentes-Osornio and Quelapio, {M. I.D.} and Tupasi, {T. E.} and J. Robert and Schaaf, {H. S.} and Seung, {K. J.} and Shin, {S. S.} and Shim, {T. S.} and Y. Shiraishi and G. Sotgiu and P. Tabarsi and Vargas, {M. H.} and J. Westenhouse and Yew, {W. W.} and Yim, {J. J.}",

note = "Publisher Copyright: Copyright {\textcopyright} ERS 2017.",

year = "2017",

month = jan,

day = "1",

doi = "10.1183/13993003.00993-2016",

language = "English (US)",

volume = "49",

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TY - JOUR

T1 - Group 5 drugs for multidrug-resistant tuberculosis

T2 - Individual patient data meta-analysis

AU - Fox, Greg J.

AU - Benedetti, Andrea

AU - Cox, Helen

AU - Koh, Won Jung

AU - Viiklepp, Piret

AU - Ahuja, Shama

AU - Pasvol, Geoffrey

AU - Menzies, Dick

AU - Ahuja, S.

AU - Ashkin, D.

AU - Avendaño, M.

AU - Banerjee, R.

AU - Bauer, M.

AU - Hollm-Delgado, M. G.

AU - Pai, M.

AU - Shah, L.

AU - Bayona, J. N.

AU - Becerra, M.

AU - Burgos, M.

AU - Centis, R.

AU - D'Ambrosio, L.

AU - Migliori, G. B.

AU - Chan, E. D.

AU - Chiang, C. Y.

AU - De Lange, W. C.M.

AU - Van Altena, R.

AU - Van Der Werf, T. S.

AU - De Riemer, K.

AU - Dung, N. H.

AU - Enarson, D.

AU - Falzon, D.

AU - Granich, R. M.

AU - Flanagan, K.

AU - Flood, J.

AU - Gandhi, N.

AU - Garcia-Garcia, L.

AU - Holtz, T. H.

AU - Iseman, M.

AU - Strand, M. J.

AU - Jarlsberg, L. G.

AU - Royce, S.

AU - Keshavjee, S.

AU - Kim, H. R.

AU - Mitnick, C. D.

AU - Lancaster, J.

AU - Van Der Walt, M.

AU - Lange, C.

AU - Leimane, V.

AU - Riekstina, V.

AU - Leung, C. C.

AU - Li, J.

AU - Narita, M.

AU - O'Riordan, P.

AU - Palmero, D.

AU - Park, S. K.

AU - Pena, J.

AU - Pérez-Guzmán, C.

AU - Ponce-De-Leon, A.

AU - Sifuentes-Osornio, J.

AU - Quelapio, M. I.D.

AU - Tupasi, T. E.

AU - Robert, J.

AU - Schaaf, H. S.

AU - Seung, K. J.

AU - Shin, S. S.

AU - Shim, T. S.

AU - Shiraishi, Y.

AU - Sotgiu, G.

AU - Tabarsi, P.

AU - Vargas, M. H.

AU - Westenhouse, J.

AU - Yew, W. W.

AU - Yim, J. J.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The role of so-called "group 5" second-line drugs as a part of antibiotic therapy for multidrug-resistant tuberculosis (MDR-TB) is widely debated. We performed an individual patient data meta-analysis to evaluate the effectiveness of several group 5 drugs including amoxicillin/clavulanic acid, thioacetazone, the macrolide antibiotics, linezolid, clofazimine and terizidone for treatment of patients with MDR-TB. Detailed individual patient data were obtained from 31 published cohort studies of MDR-TB therapy. Pooled treatment outcomes for each group 5 drug were calculated using a random effects meta-analysis. Primary analyses compared treatment success to a combined outcome of failure, relapse or death. Among 9282 included patients, 2191 received at least one group 5 drug. We found no improvement in treatment success among patients taking clofazimine, amoxicillin/clavulanic acid or macrolide antibiotics, despite applying a number of statistical approaches to control confounding. Thioacetazone was associated with increased treatment success (OR 2.6, 95% CI 1.1-6.1) when matched controls were selected from studies in which the group 5 drugs were not used at all, although this result was heavily influenced by a single study. The development of more effective antibiotics to treat drug-resistant TB remains an urgent priority.

AB - The role of so-called "group 5" second-line drugs as a part of antibiotic therapy for multidrug-resistant tuberculosis (MDR-TB) is widely debated. We performed an individual patient data meta-analysis to evaluate the effectiveness of several group 5 drugs including amoxicillin/clavulanic acid, thioacetazone, the macrolide antibiotics, linezolid, clofazimine and terizidone for treatment of patients with MDR-TB. Detailed individual patient data were obtained from 31 published cohort studies of MDR-TB therapy. Pooled treatment outcomes for each group 5 drug were calculated using a random effects meta-analysis. Primary analyses compared treatment success to a combined outcome of failure, relapse or death. Among 9282 included patients, 2191 received at least one group 5 drug. We found no improvement in treatment success among patients taking clofazimine, amoxicillin/clavulanic acid or macrolide antibiotics, despite applying a number of statistical approaches to control confounding. Thioacetazone was associated with increased treatment success (OR 2.6, 95% CI 1.1-6.1) when matched controls were selected from studies in which the group 5 drugs were not used at all, although this result was heavily influenced by a single study. The development of more effective antibiotics to treat drug-resistant TB remains an urgent priority.

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DO - 10.1183/13993003.00993-2016

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JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 1

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ER -

Group 5 drugs for multidrug-resistant tuberculosis: Individual patient data meta-analysis

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