Group 2 innate lymphoid cells in the lung

Li Yin Drake, Hirohito Kita

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s) are a subset of ILCs and are characterized by their capacity to produce large quantities of type 2 cytokines and certain tissue growth factors. In animal models, lung ILC2s are involved in allergic airway inflammation induced by exposure to allergens even in the absence of CD4+ T cells and are likely responsible for tissue repair and recovery after respiratory virus infection. ILC2s are also identified in various organs in humans, and the numbers are increased in mucosal tissues from patients with allergic disorders. Further investigations of this novel cell type will provide major conceptual advances in our understanding of the mechanisms of asthma and allergic diseases.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalAdvances in Immunology
Volume124
DOIs
StatePublished - 2014

Fingerprint

Lymphocytes
Lung
Thromboplastin
Virus Diseases
Innate Immunity
Respiratory Tract Infections
Allergens
Immune System
Intercellular Signaling Peptides and Proteins
Mucous Membrane
Homeostasis
Asthma
Animal Models
Cytokines
Inflammation
T-Lymphocytes

Keywords

  • Allergy
  • Asthma
  • Cytokines
  • Innate lymphoid cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Group 2 innate lymphoid cells in the lung. / Drake, Li Yin; Kita, Hirohito.

In: Advances in Immunology, Vol. 124, 2014, p. 1-16.

Research output: Contribution to journalArticle

@article{c8de9f944263439cba1f4589664df49c,
title = "Group 2 innate lymphoid cells in the lung",
abstract = "As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s) are a subset of ILCs and are characterized by their capacity to produce large quantities of type 2 cytokines and certain tissue growth factors. In animal models, lung ILC2s are involved in allergic airway inflammation induced by exposure to allergens even in the absence of CD4+ T cells and are likely responsible for tissue repair and recovery after respiratory virus infection. ILC2s are also identified in various organs in humans, and the numbers are increased in mucosal tissues from patients with allergic disorders. Further investigations of this novel cell type will provide major conceptual advances in our understanding of the mechanisms of asthma and allergic diseases.",
keywords = "Allergy, Asthma, Cytokines, Innate lymphoid cells",
author = "Drake, {Li Yin} and Hirohito Kita",
year = "2014",
doi = "10.1016/B978-0-12-800147-9.00001-7",
language = "English (US)",
volume = "124",
pages = "1--16",
journal = "Advances in Immunology",
issn = "0065-2776",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Group 2 innate lymphoid cells in the lung

AU - Drake, Li Yin

AU - Kita, Hirohito

PY - 2014

Y1 - 2014

N2 - As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s) are a subset of ILCs and are characterized by their capacity to produce large quantities of type 2 cytokines and certain tissue growth factors. In animal models, lung ILC2s are involved in allergic airway inflammation induced by exposure to allergens even in the absence of CD4+ T cells and are likely responsible for tissue repair and recovery after respiratory virus infection. ILC2s are also identified in various organs in humans, and the numbers are increased in mucosal tissues from patients with allergic disorders. Further investigations of this novel cell type will provide major conceptual advances in our understanding of the mechanisms of asthma and allergic diseases.

AB - As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s) are a subset of ILCs and are characterized by their capacity to produce large quantities of type 2 cytokines and certain tissue growth factors. In animal models, lung ILC2s are involved in allergic airway inflammation induced by exposure to allergens even in the absence of CD4+ T cells and are likely responsible for tissue repair and recovery after respiratory virus infection. ILC2s are also identified in various organs in humans, and the numbers are increased in mucosal tissues from patients with allergic disorders. Further investigations of this novel cell type will provide major conceptual advances in our understanding of the mechanisms of asthma and allergic diseases.

KW - Allergy

KW - Asthma

KW - Cytokines

KW - Innate lymphoid cells

UR - http://www.scopus.com/inward/record.url?scp=84906733460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906733460&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-800147-9.00001-7

DO - 10.1016/B978-0-12-800147-9.00001-7

M3 - Article

C2 - 25175771

AN - SCOPUS:84906733460

VL - 124

SP - 1

EP - 16

JO - Advances in Immunology

JF - Advances in Immunology

SN - 0065-2776

ER -