Group 2 innate lymphoid cells in the lung

Li Yin Drake, Hirohito Kita

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations

Abstract

As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s) are a subset of ILCs and are characterized by their capacity to produce large quantities of type 2 cytokines and certain tissue growth factors. In animal models, lung ILC2s are involved in allergic airway inflammation induced by exposure to allergens even in the absence of CD4+ T cells and are likely responsible for tissue repair and recovery after respiratory virus infection. ILC2s are also identified in various organs in humans, and the numbers are increased in mucosal tissues from patients with allergic disorders. Further investigations of this novel cell type will provide major conceptual advances in our understanding of the mechanisms of asthma and allergic diseases.

Original languageEnglish (US)
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc
Pages1-16
Number of pages16
DOIs
StatePublished - 2014

Publication series

NameAdvances in Immunology
Volume124
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Keywords

  • Allergy
  • Asthma
  • Cytokines
  • Innate lymphoid cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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