GRN Mutations Are Associated with Lewy Body Dementia

the International LBD Genomics Consortium, The American Genome Center

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Loss-of-function mutations in GRN are a cause of familial frontotemporal dementia, and common variants within the gene have been associated with an increased risk of developing Alzheimer's disease and Parkinson's disease. Although TDP-43-positive inclusions are characteristic of GRN-related neurodegeneration, Lewy body copathology has also been observed in many GRN mutation carriers. Objective: The objective of this study was to assess a Lewy body dementia (LBD) case–control cohort for pathogenic variants in GRN and to test whether there is an enrichment of damaging mutations among patients with LBD. Methods: We analyzed whole-genome sequencing data generated for 2591 European-ancestry LBD cases and 4032 neurologically healthy control subjects to identify disease-causing mutations in GRN. Results: We identified six heterozygous exonic GRN mutations in seven study participants (cases: n = 6; control subjects: n = 1). Each variant was predicted to be pathogenic or likely pathogenic. We found significant enrichment of GRN loss-of-function mutations in patients with LBD compared with control subjects (Optimized Sequence Kernel Association Test P = 0.0162). Immunohistochemistry in three definite LBD cases demonstrated Lewy body pathology and TDP-43-positive neuronal inclusions. Conclusions: Our findings suggest that deleterious GRN mutations are a rare cause of familial LBD.

Original languageEnglish (US)
JournalMovement Disorders
DOIs
StateAccepted/In press - 2022

Keywords

  • frontotemporal lobar degeneration (FTLD)
  • GRN mutations
  • Lewy body dementia (LBD)
  • neurodegeneration
  • progranulin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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