Grip strength predicts cardiac adverse events in patients with cardiac disorders

An individual patient pooled meta-analysis

Rita Pavasini, Matteo Serenelli, Carlos A. Celis-Morales, Stuart R. Gray, Kazuhiro P. Izawa, Satoshi Watanabe, Eloisa Colin-Ramirez, Lilia Castillo-Martínez, Yasuhiro Izumiya, Shinsuke Hanatani, Yoshiro Onoue, Kenichi Tsujita, Peter S. Macdonald, Sunita R. Jha, Veronique Lee Roger, Sheila M. Manemann, Juan Sanchis, Vicente Ruiz, Giulia Bugani, Elisabetta Tonet & 3 others Roberto Ferrari, Stefano Volpato, Gianluca Campo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Grip strength is a well-characterised measure of weakness and of poor muscle performance, but there is a lack of consensus on its prognostic implications in terms of cardiac adverse events in patients with cardiac disorders. Methods: Articles were searched in PubMed, Cochrane Library, BioMed Central and EMBASE. The main inclusion criteria were patients with cardiac disorders (ischaemic heart disease, heart failure (HF), cardiomyopathies, valvulopathies, arrhythmias); evaluation of grip strength by handheld dynamometer; and relation between grip strength and outcomes. The endpoints of the study were cardiac death, all-cause mortality, hospital admission for HF, cerebrovascular accident (CVA) and myocardial infarction (MI). Data of interest were retrieved from the articles and after contact with authors, and then pooled in an individual patient meta-analysis. Univariate and multivariate logistic regression was performed to define predictors of outcomes. Results: Overall, 23 480 patients were included from 7 studies. The mean age was 62.3±6.9 years and 70% were male. The mean follow-up was 2.82±1.7 years. After multivariate analysis grip strength (difference of 5 kg, 5× kg) emerged as an independent predictor of cardiac death (OR 0.84, 95% CI 0.79 to 0.89, p<0.0001), all-cause death (OR 0.87, 95% CI 0.85 to 0.89, p<0.0001) and hospital admission for HF (OR 0.88, 95% CI 0.84 to 0.92, p<0.0001). On the contrary, we did not find any relationship between grip strength and occurrence of MI or CVA. Conclusion: In patients with cardiac disorders, grip strength predicted cardiac death, all-cause death and hospital admission for HF. Trial registration number: CRD42015025280.

Original languageEnglish (US)
JournalHeart
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Hand Strength
Meta-Analysis
Heart Failure
Cause of Death
Stroke
Myocardial Infarction
Muscle Weakness
Hospital Mortality
Cardiomyopathies
PubMed
Libraries
Myocardial Ischemia
Cardiac Arrhythmias
Multivariate Analysis
Logistic Models

Keywords

  • heart disease
  • heart failure
  • meta-analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pavasini, R., Serenelli, M., Celis-Morales, C. A., Gray, S. R., Izawa, K. P., Watanabe, S., ... Campo, G. (Accepted/In press). Grip strength predicts cardiac adverse events in patients with cardiac disorders: An individual patient pooled meta-analysis. Heart. https://doi.org/10.1136/heartjnl-2018-313816

Grip strength predicts cardiac adverse events in patients with cardiac disorders : An individual patient pooled meta-analysis. / Pavasini, Rita; Serenelli, Matteo; Celis-Morales, Carlos A.; Gray, Stuart R.; Izawa, Kazuhiro P.; Watanabe, Satoshi; Colin-Ramirez, Eloisa; Castillo-Martínez, Lilia; Izumiya, Yasuhiro; Hanatani, Shinsuke; Onoue, Yoshiro; Tsujita, Kenichi; Macdonald, Peter S.; Jha, Sunita R.; Roger, Veronique Lee; Manemann, Sheila M.; Sanchis, Juan; Ruiz, Vicente; Bugani, Giulia; Tonet, Elisabetta; Ferrari, Roberto; Volpato, Stefano; Campo, Gianluca.

In: Heart, 01.01.2018.

Research output: Contribution to journalArticle

Pavasini, R, Serenelli, M, Celis-Morales, CA, Gray, SR, Izawa, KP, Watanabe, S, Colin-Ramirez, E, Castillo-Martínez, L, Izumiya, Y, Hanatani, S, Onoue, Y, Tsujita, K, Macdonald, PS, Jha, SR, Roger, VL, Manemann, SM, Sanchis, J, Ruiz, V, Bugani, G, Tonet, E, Ferrari, R, Volpato, S & Campo, G 2018, 'Grip strength predicts cardiac adverse events in patients with cardiac disorders: An individual patient pooled meta-analysis', Heart. https://doi.org/10.1136/heartjnl-2018-313816
Pavasini, Rita ; Serenelli, Matteo ; Celis-Morales, Carlos A. ; Gray, Stuart R. ; Izawa, Kazuhiro P. ; Watanabe, Satoshi ; Colin-Ramirez, Eloisa ; Castillo-Martínez, Lilia ; Izumiya, Yasuhiro ; Hanatani, Shinsuke ; Onoue, Yoshiro ; Tsujita, Kenichi ; Macdonald, Peter S. ; Jha, Sunita R. ; Roger, Veronique Lee ; Manemann, Sheila M. ; Sanchis, Juan ; Ruiz, Vicente ; Bugani, Giulia ; Tonet, Elisabetta ; Ferrari, Roberto ; Volpato, Stefano ; Campo, Gianluca. / Grip strength predicts cardiac adverse events in patients with cardiac disorders : An individual patient pooled meta-analysis. In: Heart. 2018.
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abstract = "Objective: Grip strength is a well-characterised measure of weakness and of poor muscle performance, but there is a lack of consensus on its prognostic implications in terms of cardiac adverse events in patients with cardiac disorders. Methods: Articles were searched in PubMed, Cochrane Library, BioMed Central and EMBASE. The main inclusion criteria were patients with cardiac disorders (ischaemic heart disease, heart failure (HF), cardiomyopathies, valvulopathies, arrhythmias); evaluation of grip strength by handheld dynamometer; and relation between grip strength and outcomes. The endpoints of the study were cardiac death, all-cause mortality, hospital admission for HF, cerebrovascular accident (CVA) and myocardial infarction (MI). Data of interest were retrieved from the articles and after contact with authors, and then pooled in an individual patient meta-analysis. Univariate and multivariate logistic regression was performed to define predictors of outcomes. Results: Overall, 23 480 patients were included from 7 studies. The mean age was 62.3±6.9 years and 70{\%} were male. The mean follow-up was 2.82±1.7 years. After multivariate analysis grip strength (difference of 5 kg, 5× kg) emerged as an independent predictor of cardiac death (OR 0.84, 95{\%} CI 0.79 to 0.89, p<0.0001), all-cause death (OR 0.87, 95{\%} CI 0.85 to 0.89, p<0.0001) and hospital admission for HF (OR 0.88, 95{\%} CI 0.84 to 0.92, p<0.0001). On the contrary, we did not find any relationship between grip strength and occurrence of MI or CVA. Conclusion: In patients with cardiac disorders, grip strength predicted cardiac death, all-cause death and hospital admission for HF. Trial registration number: CRD42015025280.",
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T1 - Grip strength predicts cardiac adverse events in patients with cardiac disorders

T2 - An individual patient pooled meta-analysis

AU - Pavasini, Rita

AU - Serenelli, Matteo

AU - Celis-Morales, Carlos A.

AU - Gray, Stuart R.

AU - Izawa, Kazuhiro P.

AU - Watanabe, Satoshi

AU - Colin-Ramirez, Eloisa

AU - Castillo-Martínez, Lilia

AU - Izumiya, Yasuhiro

AU - Hanatani, Shinsuke

AU - Onoue, Yoshiro

AU - Tsujita, Kenichi

AU - Macdonald, Peter S.

AU - Jha, Sunita R.

AU - Roger, Veronique Lee

AU - Manemann, Sheila M.

AU - Sanchis, Juan

AU - Ruiz, Vicente

AU - Bugani, Giulia

AU - Tonet, Elisabetta

AU - Ferrari, Roberto

AU - Volpato, Stefano

AU - Campo, Gianluca

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: Grip strength is a well-characterised measure of weakness and of poor muscle performance, but there is a lack of consensus on its prognostic implications in terms of cardiac adverse events in patients with cardiac disorders. Methods: Articles were searched in PubMed, Cochrane Library, BioMed Central and EMBASE. The main inclusion criteria were patients with cardiac disorders (ischaemic heart disease, heart failure (HF), cardiomyopathies, valvulopathies, arrhythmias); evaluation of grip strength by handheld dynamometer; and relation between grip strength and outcomes. The endpoints of the study were cardiac death, all-cause mortality, hospital admission for HF, cerebrovascular accident (CVA) and myocardial infarction (MI). Data of interest were retrieved from the articles and after contact with authors, and then pooled in an individual patient meta-analysis. Univariate and multivariate logistic regression was performed to define predictors of outcomes. Results: Overall, 23 480 patients were included from 7 studies. The mean age was 62.3±6.9 years and 70% were male. The mean follow-up was 2.82±1.7 years. After multivariate analysis grip strength (difference of 5 kg, 5× kg) emerged as an independent predictor of cardiac death (OR 0.84, 95% CI 0.79 to 0.89, p<0.0001), all-cause death (OR 0.87, 95% CI 0.85 to 0.89, p<0.0001) and hospital admission for HF (OR 0.88, 95% CI 0.84 to 0.92, p<0.0001). On the contrary, we did not find any relationship between grip strength and occurrence of MI or CVA. Conclusion: In patients with cardiac disorders, grip strength predicted cardiac death, all-cause death and hospital admission for HF. Trial registration number: CRD42015025280.

AB - Objective: Grip strength is a well-characterised measure of weakness and of poor muscle performance, but there is a lack of consensus on its prognostic implications in terms of cardiac adverse events in patients with cardiac disorders. Methods: Articles were searched in PubMed, Cochrane Library, BioMed Central and EMBASE. The main inclusion criteria were patients with cardiac disorders (ischaemic heart disease, heart failure (HF), cardiomyopathies, valvulopathies, arrhythmias); evaluation of grip strength by handheld dynamometer; and relation between grip strength and outcomes. The endpoints of the study were cardiac death, all-cause mortality, hospital admission for HF, cerebrovascular accident (CVA) and myocardial infarction (MI). Data of interest were retrieved from the articles and after contact with authors, and then pooled in an individual patient meta-analysis. Univariate and multivariate logistic regression was performed to define predictors of outcomes. Results: Overall, 23 480 patients were included from 7 studies. The mean age was 62.3±6.9 years and 70% were male. The mean follow-up was 2.82±1.7 years. After multivariate analysis grip strength (difference of 5 kg, 5× kg) emerged as an independent predictor of cardiac death (OR 0.84, 95% CI 0.79 to 0.89, p<0.0001), all-cause death (OR 0.87, 95% CI 0.85 to 0.89, p<0.0001) and hospital admission for HF (OR 0.88, 95% CI 0.84 to 0.92, p<0.0001). On the contrary, we did not find any relationship between grip strength and occurrence of MI or CVA. Conclusion: In patients with cardiac disorders, grip strength predicted cardiac death, all-cause death and hospital admission for HF. Trial registration number: CRD42015025280.

KW - heart disease

KW - heart failure

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